Patents by Inventor Pablo Rubinstein

Pablo Rubinstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240060213
    Abstract: The present specification provides libraries of HLA homozygous induced pluripotent cell
    Type: Application
    Filed: October 27, 2023
    Publication date: February 22, 2024
    Inventors: Pablo Rubinstein, Christopher D. Hillyer
  • Patent number: 11834757
    Abstract: The present specification provides libraries of HLA homozygous induced pluripotent cell lines.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: December 5, 2023
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Christopher D. Hillyer
  • Publication number: 20210230772
    Abstract: The present specification provides libraries of HLA homozygous induced pluripotent cell lines.
    Type: Application
    Filed: December 5, 2018
    Publication date: July 29, 2021
    Inventor: Pablo Rubinstein
  • Publication number: 20100047858
    Abstract: Disclosed herein is a high throughput system for the objective, standardized determination of colony forming units in populations of hematopoietic cells and indication of successful engraftment. Further disclosed is a laboratory information management system that provides electronic storage of images and data associated with cord blood units.
    Type: Application
    Filed: August 20, 2009
    Publication date: February 25, 2010
    Inventors: Maria S. Albano, William Rothman, Pablo Rubinstein
  • Publication number: 20070179424
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Application
    Filed: December 15, 2006
    Publication date: August 2, 2007
    Inventors: Pablo Rubinstein, Philip Coelho, Cladd Stevens
  • Patent number: 7169547
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: January 30, 2007
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
  • Publication number: 20060068369
    Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.
    Type: Application
    Filed: September 30, 2004
    Publication date: March 30, 2006
    Inventors: Philip Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Pablo Rubinstein
  • Patent number: 6808675
    Abstract: A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed with their larger planar surfaces in contact with each other.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: October 26, 2004
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Pablo Rubinstein
  • Publication number: 20030191005
    Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.
    Type: Application
    Filed: April 8, 2002
    Publication date: October 9, 2003
    Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Pablo Rubinstein
  • Patent number: 6491678
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: December 10, 2002
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
  • Publication number: 20010034513
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Application
    Filed: May 15, 2001
    Publication date: October 25, 2001
    Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
  • Patent number: 6302327
    Abstract: A system and method for controlled rate freezing and storage of thermolabile substances. The system includes a storage unit for receiving product stored within a bag and an overlying protective canister associated with a robotic arm and reading device which places the canister in the preserving environment. A control system, driven by a computer monitors the ingress, egress and storage location and particularized profiles of the articles being placed in storage.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: October 16, 2001
    Assignee: ThermoGenesis, Corp.
    Inventors: Philip H. Coelho, Pablo Rubinstein, Mark Buckley, Kevin Pelletier
  • Patent number: 6232115
    Abstract: A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: May 15, 2001
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Pablo Rubinstein
  • Patent number: 6146124
    Abstract: A mold is disclosed for forming a freezable and thawable bag of uniform thickness, especially useful for cryopreservation of thermolabile substances. The mold features one or more recessed planar surfaces, including radiused peripheral walls about the recesses, a planar top surface, and means for conforming a blank sheet to the mold. Two mold halves combine to form a completed bag. The mold halves may be complimentary.
    Type: Grant
    Filed: June 25, 1996
    Date of Patent: November 14, 2000
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Pablo Rubinstein
  • Patent number: 6123696
    Abstract: A method and apparatus for the sequestration of components of a fluid by forcing heavier fractions of the fluid to pass beyond a yieldable partition integrally formed within a bag. Fluid fractions remain sequestered within bag compartments when forces driving the heavier fraction have been removed.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: September 26, 2000
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Pablo Rubinstein
  • Patent number: 5964095
    Abstract: A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: October 12, 1999
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Terry Wolf, Pablo Rubinstein
  • Patent number: 5928214
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: July 27, 1999
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
  • Patent number: 5789147
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: August 4, 1998
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
  • Patent number: 5638686
    Abstract: A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.
    Type: Grant
    Filed: February 23, 1995
    Date of Patent: June 17, 1997
    Assignee: ThermoGenesis Corporation
    Inventors: Philip Henry Coelho, Terry Wolf, Pablo Rubinstein
  • Patent number: 5101017
    Abstract: A monoclonal antibody which identifies the human blood group Duffy (ab) is provided. Such monoclonal antibody blocks the penetration of P. vivax malaria parasite into human red blood cells by virtue of effective blocking of the target molecule of the P. vivax malaria parasite. Such monoclonal antibody has a combining site having the same stereochemistry as the ligand site on P. vivax, and elicits anti-idiotypic antibodies that react with the parasite.
    Type: Grant
    Filed: April 6, 1987
    Date of Patent: March 31, 1992
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Margaret Nichols