Patents by Inventor Padmaja Mantri

Padmaja Mantri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
    Patent number: 5658885
    Abstract: This invention relates to Novel .alpha.-aminoacid and .alpha.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: August 19, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Sheng-Lian O. Lee, David John Carini, John Matthew Fevig, Charles Adrian Kettner, Padmaja Mantri, Zixia Feng
  • Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
    Patent number: 5656662
    Abstract: The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 12, 1997
    Assignee: The Ohio State University Research Foundation
    Inventors: Padmaja Mantri, Donald T. Witiak
  • Optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids and pharmaceutical use thereof
    Patent number: 5504107
    Abstract: The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. The invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: April 2, 1996
    Assignee: The Ohio State University Research Foundation
    Inventors: Padmaja Mantri, Donald T. Witiak