Abstract: A system and method including receiving a request to update a timestamp associated with database pages of a database instance logically organized into at least one page set, each of the at least one page set including a plurality of the database pages; updating the timestamp associated with each database page in each respective at least one page set; issuing, in response to updating the timestamp associated with a last database page in each of the at least one page set, a write request to write the plurality of database pages in each of the respective at least one page set to a persistent data store; and writing the plurality of database pages in each of the respective at least one page set to a persistent data store, the plurality of database pages written to the persistent data store having an updated timestamp associated therewith.

Abstract: The present invention encompasses; the novel substituted heterocyclic compounds represented by formula (I) or their pharmaceutically acceptable salts, wherein the substituents in formula (I) have the meanings as defined in the specification. The invention also encompasses process for preparing such compound, pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.