Patents by Inventor Padmavathi Sampath

Padmavathi Sampath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
    Patent number: 11786569
    Abstract: Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF-1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: October 17, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Greg M. Delgoffe, Dayana Rivadeneira, Padmavathi Sampath, Stephen H. Thorne
  • EXPRESSION OF METABOLIC MODULATORS IN TUMOR MICROENVIRONMENT TO IMPROVE TUMOR THERAPY
    Publication number: 20200330534
    Abstract: Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF-1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
    Type: Application
    Filed: January 28, 2019
    Publication date: October 22, 2020
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Greg M. Delgoffe, Dayana Rivadeneira, Padmavathi Sampath, Stephen H. Thorne