Abstract: A method of biochemical processing may, in certain embodiments, involve the steps of use of a consumable biochemical process element and a consumable biochemical process alterable information memory element associated therewith, such as a substance withdrawal consumable biochemical process alterable information memory element, that may be queried and at least some of whose information may be changed as a result of actions conducted during processing of a biochemical test sequence. Accordingly, advantages relative to knowing how much of a consumable biochemical process element has been used, and how much may be available during a biochemical test sequence, may be achieved.

Abstract: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.

Abstract: A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minute to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.

Abstract: A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: This present invention covers novel means, devices and instruments for production of a tissue array block that is further sectioned into duplicates of tissue arrays. An integral microscope is incorporated into the instrument for viewing and examining a stained reference slide and selecting donor tissue core region(s) from the reference slide. The reference slide is held in a reference slide station that is operatively linked and indexed with a station or platform holding a source donor tissue block, which is further indexed and precisely positioned with reference to the donor needle punch for punching the donor tissue core(s). A recipient block indexed to the donor block punch is placed under the donor punch station and donor tissue cores are delivered into pre-existing hole(s) by a stylet to construct the tissue array block. The instrument includes a donor punch station, optionally a second recipient punch station, with each operable independently or removable.

Abstract: This present invention covers novel means, devices and instruments for production of a tissue array block that is further sectioned into duplicates of tissue arrays. An integral microscope is incorporated into the instant instrument for viewing and examining a stained reference slide and selecting donor tissue core region(s) from the reference slide. The said reference slide is held in a reference slide station that is operatively linked and indexed with a station or platform holding a source donor tissue block, which is further indexed and precisely positioned with reference to the donor punch needle for punching the donor tissue core(s). A recipient block indexed to the donor block punch is placed under the donor punch station and donor tissue cores are delivered into pre-existing hole(s) by a stylet to construct the tissue array block. The instant instrument comprises a donor punch station, optionally a second recipient punch station, with each operable independently or removable.

Abstract: A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among the plurality of processing stations, and a processor, which may select the order, timing and location of the tissue sample. The robotic device may comprise a bench robot with rectilinear motion or a rotatable tower. The processing stations may be disposed in a set of grid locations, which comprise workstations for performing individual steps of the procedures. In response to timing information about the procedures, the processor may select the sample to be moved.

Abstract: A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among a plurality of processing stations, and a processor, which may select the next tissue sample to move, when to move it, and where to move it to. The processor may direct the robotic arm to interleave the differing process steps. The processor may select a tissue sample to be moved in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences.

Abstract: A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which moves the different tissue samples among a plurality of processing stations, and a processor, which selects the next tissue sample to move, when to move it, and where to move it to. The processor directs the robotic arm to interleave the differing process steps. The processing stations comprise workstations for performing individual steps of the tissue assay procedures, such as solution trays. The processor selects a tissue sample to be moved in response to timing information about the procedures. While the processor is directing the robotic arm to move, the processor monitors progress information and can alter the sequence of process steps in response to the progress information and information from an operator.

Abstract: A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among the plurality of processing stations, and a processor, which may select the order, timing and location of the tissue sample. The robotic device may comprise a bench robot with rectilinear motion or a rotatable tower. The processing stations may be disposed in a set of grid locations, which comprise workstations for performing individual steps of the procedures. In response to timing information about the procedures, the processor may select the sample to be moved.

Abstract: A system for performing a plurality of independent analysis procedures simultaneously, each procedure having a sample and at least one process step for operating on that sample the system having a robotic device for moving a sample among a plurality of processing stations where the robotic device comprises substrate to which are coupled a plurality of tiles each one of the tiles disposed at a selected location on the substrate; a plurality of reagent trays coupled to the tiles, each one of the reagent trays having substantially identical shape and size; a robotic arm disposed for reaching substantially all the tiles; and capable of coupling and decoupling from a sample holder, the sample holder capable of holding at least one sample in a selected position, whereby the robotic arm is capable of moving the sample from a first one of the reagent trays to a second one of the reagent trays; and a processor for selecting, at a plurality of times a sample to be moved, and for directing the robotic arm to move the sa

Abstract: A system for performing a plurality of independent analysis procedures simultaneously, each the procedure having a sample and at least one process step for operating on that sample the system having a robotic device for moving sample among a plurality of processing stations where the robotic device comprises substrate to which are coupled a plurality of tiles each one of the tiles disposed art a selected location on the substrate; a plurality of reagent trays coupled to the tiles each one of the reagent trays having substantially identical shape and size; a robotic arm disposed for reaching substantially all the tiles; and comprising means for coupling and decoupling from a sample holder, the sample holder having a means for holding at least one sample in a selected position, whereby the robotic arm is capable of moving the sample from a first one of the reagent trays to a second one of the reagent trays; and a processor for selecting, at a plurality of times a sample to be moved, and for directing the roboti

Abstract: A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic device, which may cause the different tissue samples to be processed by processing stations, and a processor, which may select the next process step. The processor may direct the robotic device to interleave the differing process steps. The processor may select a next process step in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences.

Abstract: A system which performs a plurality of independent analysis procedures simultaneously, comprising a robotic arm and a processor, which may direct the robotic arm to interleave the differing process steps. The processor may select a tissue sample to be moved in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences. The processor may also optimize the order in which samples are moved to minimize the total time required by the system to complete the procedures, e.g.