Patents by Inventor Paivi Lehtovaara-Helenius

Paivi Lehtovaara-Helenius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast strains producing cellulolytic enzymes and methods and means for constructing them
    Patent number: 5766915
    Abstract: Functional derivatives of endoglucanase I (EGI), and the cloning and recombinant expression thereof, are described.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: June 16, 1998
    Assignee: Alko-Yhtiot Oy (Alko Group Ltd.)
    Inventors: Jonathan Knowles, Merja Penttila, Tuula Teeri, Helena Nevalainen, Paivi Lehtovaara-Helenius, Sirpa Aho, Sunee Nitisinprasert, Marja Paloheimo, Sirkka Keranen
  • Method of making endoglucanase I
    Patent number: 5529919
    Abstract: Described are methods and means for the construction of strains of yeast capable of producing cellulolytic enzymes. This is achieved by the transfer of chromosomal genes or cDNA copies of mRNAs coding for cellulolytic enzymes isolated from the fungus Trichoderma reesei to yeast cells using recombinant DNA vectors capable of replicating in yeast. The correct expression of these cellulolytic genes in yeast leads to the production of cellulolytic enzymes which are secreted from the cell. This allows the yeast to hydrolyze 3-1,4-glucan substrates such as cellulose.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: June 25, 1996
    Assignee: Alko-Yhtiot Oy
    Inventors: Jonathan Knowles, Merja Penttila, Tuula Teeri, Helena Nevalainen, Paivi Lehtovaara-Helenius
  • DNA, vectors and transformed hosts encoding Trichoderma reesei endoglucanase I
    Patent number: 5393670
    Abstract: Methods and means for the construction of strains of yeast capable of producing cellulolytic enzymes, achieved by the transfer of chromosomal genes or cDNA copies of mRNAs coding for cellulolytic enzymes isolated from the fungus Trichoderma reesei to yeast cells using recombinant DNA vectors capable of replicating in yeast. The correct expression of these cellulolytic genes in yeast leads to the production of cellulolytic enzymes which are secreted from the cell. This allows the yeast to hydrolyze 3-1,4-glucan substrates such as cellulose.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: February 28, 1995
    Assignee: Oy Alko AB
    Inventors: Jonathan Knowles, Merja Penttila, Tuula Teeri, Helena M. K. Nevalainen, Paivi Lehtovaara-Helenius
  • Yeast strains producing cellulolytic enzymes and methods and means for constructing them
    Patent number: 4894338
    Abstract: The full length DNA sequence encoding the mature cellobiohydrolase II(CHBII), as well as the DNA sequence encoding the CBHII signal sequence, have been isolated and cloned from the fungus Trichoderma reesei. Recombinant vectors comprising these sequences, and yeast hosts transformed with such vectors are disclosed. Also disclosed are methods for constructing the vectors and hosts according to the invention, as well as methods for expressing the disclosed sequences. CBHII is involved in hydrolysis of cellulose.
    Type: Grant
    Filed: January 30, 1986
    Date of Patent: January 16, 1990
    Assignee: Oy Alko AB
    Inventors: Jonathan Knowles, Merja Penttila, Tuula Teeri, Helena Nevalainen, Irma Salovuori, Paivi Lehtovaara-Helenius