Abstract: A computer based system and method for sending data packets over a data network may include: preparing data packets and packet descriptors on one or more graphical processing units (GPUs); associating packets with a packet descriptor, which may determine a desired transmission time of the packets associated with that descriptor; receiving an indication of a clock time; and physically transmitting packets via an output interface, at a clock time corresponding to the desired transmission time. A computer based system and method for GPU-initiated communication over a 5G data network may include allocating one or more memory buffers in GPU memory; performing at least one 5G signal processing procedure by a GPU; preparing descriptors for a plurality of packets, where each packet includes allocated memory buffers, and where the descriptors provide scheduling instructions for the packets; and triggering the sending of packets over the network based on prepared descriptors.