Patents by Inventor Pal Fekete
Pal Fekete has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060258745Abstract: The invention relates to tablets comprising deramciclane-fumarate of the Formula (I) whereby said tablets contain (related to the total weight) more than 50% by weight of deramciclane-fumarate, 5-20% by weight of a 5-20% by weight of microcrystalline cellulose having an average particle size below 30 ?m, 1-10% by weight of a disintegrant, 0.54% by weight of a lubricant, 0.54% by weight of an anti-adhesive agent and 0-30% by weight of a filler. ingredient.Type: ApplicationFiled: June 3, 2004Publication date: November 16, 2006Applicant: EGIS GYOGYSZERGYAR RT.Inventors: Pál Fekete, Lászlóné Maroshelyi, Zsolt Zsigmond, Lászlóné Góra, Magdolna Leventiszné Huszár, Istvànné Jámbor, József Tari
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Publication number: 20050163836Abstract: The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5-30% of microcrystalline cellulose—90% of which have a particle size that is lower than 50 Sg(m)m, and the amount of the microcrystalline cellulose refers to the final tablet mass in water and/or ethanol and/or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.Type: ApplicationFiled: April 29, 2002Publication date: July 28, 2005Inventors: Pal Fekete, Maria Ignacz, Zsuzsa Szlavyne Szell, Laszione Gora, Zoltanne Palfi, Istvanne Jambor
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Patent number: 5726201Abstract: The invention relates to oral solid pharmaceutical composition containing as active ingredient gemfibrozil and conventional pharmaceutical auxiliary agents comprising as surfactant bis-(2-ethyl-hexyl)-sodium-sulfosuccinate in an amount of 0.05-0.5% by weight relative to gemfibrozil content of the composition.The pharmaceutical compositions according to the present invention contain a relatively small amount of a surfactant, provide uniform dissolution of the active ingredient among the different batches and the standard deviation of the dissolution rate is low.Type: GrantFiled: May 15, 1995Date of Patent: March 10, 1998Assignee: Egis Gyogyszergyar Rt.Inventors: Pal Fekete, Erzsebet Fellner, nee Kohalmi, Andrea Sandorfalvy, Denes Bezzegh, Gyorgy Ujfalussy, Magdolna Gora, nee Hernyes, Imre Klebovich, Sandor Drabant, Attila Mandi, Biborka Maroshelyi, nee Kovacs, Marta Szanto, Zsuzsa Szlavy, nee Szell
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Patent number: 5543155Abstract: The invention relates to a novel diffusion-osmotic controlled drug-release pharmaceutical composition containing a one-layer tablet core including a polymeric film-coat, a therapeutically active agent and a hydrophilic polymer; if desired, a two-layer tablet core including active agent and hydrophilic polymer in the first layer thereof and a hydrophilic polymer in the second layer thereof; at least one bore on the part of film-coat in contact with the core or core layer containing the active agent; and, if desired, containing one or more bore(s) in the part thereof in contact with the second layer containing the hydrophilic polymer, which comprises an ammonium methacrylate copolymer as coating material and hydroxypropyl-methylcellulose as hydrophilic polymer. The composition according to the invention is useful for preparing controlled drug-release tablets containing as active agents e.g. .beta.-adrenergic inhibitors (e.g. propranolol) calcium-antagonists (e.g.Type: GrantFiled: December 5, 1994Date of Patent: August 6, 1996Assignee: Egis Gyogyszergyar Rt.Inventors: Pal Fekete, Maria Kiraly nee Ignacz, Gabor Sipos, Zsuzsanna Jambor nee Hoffmann, Gyorgy Ujfalussy, Magdolna Gora nee Hernyes, Imre Klebovich, Sandor Drabant, Attila Mandi, Gizella Kiss nee Szabo, Erzsebet Barczay, Maria Krisztian
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Patent number: 5391737Abstract: This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium.The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds.The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.Type: GrantFiled: November 24, 1993Date of Patent: February 21, 1995Assignee: EGIS GyogyszergyarInventors: Jozsef Reiter, Peter Trinka, Peter Tompe, Eva Szabo, Peter Slegel, Janos Brlik, Agnes Halbauer nee Nagy, Ilona Sztruhar, Magdolna Kenyeres nee Feher, Frigyes Gorgenyi, Margit Csorgo, Szvetlana Zsarnoczai nee Kurnyecova, Sarolta Benko nee Markus, Gabor Gigler, Dezso Danyi, Pal Fekete, Maria Kiraly nee Ignacz
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Patent number: 5192552Abstract: The invention relates to the preparation of microcapsules ensuring direct tablet compression of a drug and rapid release of the drug as active ingredient from the tablets, which comprises microencapsulating the crystal granules of cyclohexane-insoluble active ingredients with a particle size of at most 1000 .mu.m, preferably smaller than 60 .mu.m and particularly preferably smaller than 30 .mu.m, in cyclohexane medium with ethylcellulose taken in an amount of 1:30 to 1:5, preferably 1:20 to 1:10, in relation to the core material, if desired, in the presence of 0.001 to 1.0% by weight/volume, preferably 0.01 to 0.05% by weight/volume, of an anionic surface-active agent; or post-treating the drug granules microencapsulated with ethylcellulose by a cyclohexane-dissolved surface-active agent taken in an amount of 0.001 to 1.0% by weight/volume, preferably 0.1 to 0.5% by weight/volume, in relation to cyclohexane.Type: GrantFiled: December 29, 1989Date of Patent: March 9, 1993Assignee: EGIS GyogyszergyarInventors: Pal Fekete, Denes Bezzegh, Katalin Zukovics neSte,uml/u/ megh, Zsuzsanna Jambor neHoffmann, Janos Tombor
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Patent number: 5120711Abstract: The invention relates to synergistically active veterinary compositions useful particularly for the treatment of mastitis and metritis. The invention further relates to a process for preparing these compositions. The compositions according to the invention comprise, based on 1 part by weight of 6,9,18-tris(2-aminoethyl) -15-benzyl-21-[.sup.- 2,8-bis(2-aminoethyl)-5-(1-hydroxyethyl) -15-methyl-4,7,10-trioxo-3,6,9-triazaheptadecanamido]-3-(1-hydroxyethyl)-1 2-isobutyl-1,4,7,10,13,16,19-heptaazacyclotricosane-2, 5,8,11,14,17,20-heptaone or a pharmaceutically acceptable acid addition salt thereof, 1 to 1000 parts by weight of 1-(2-chlorophenyl)-diphenylmethyl-1H-imidazole or 1 to 400 parts by weight of 2-methyl-5,7-dichloro-8-hydroxyquinoline, respectively, optionally in admixture with carriers and/or additives commonly used in the pharmaceutical industry.Type: GrantFiled: November 20, 1990Date of Patent: June 9, 1992Assignee: EGIS GyogyszergyarInventors: Karoly Magyar, Ferenc Simon, Janos Varga, Attila Nagy, Laszlo Puskas, Pal Fekete, Janos Egri, Katalin Zukovics
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Patent number: 5047434Abstract: The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of 1-(3,5-dihydroxyphenyl)-2-(tertiary butylamino)-ethanol or a physiologically acceptable acid addition salt thereof as active ingredient in admixture with inert solid and/or liquid carrier(s).Type: GrantFiled: July 5, 1989Date of Patent: September 10, 1991Assignee: Egis GyogyszergyarInventors: Ferenc Simon, Karoly Magyar, Attila Nagy, Lajos Fekete, Laszlo Puskas, Pal Fekete, Istvan Simonyi, Janos Egri, Katalin Zukovics nee Sumeg
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Patent number: 4871722Abstract: The invention relates to a synergistic veterinary composition and/or a fodder premix useful for preventing or curing bacterial, fungal and protozoic infection particularly occurring at poultry species. Furthermore the invention relates to a process for preparing same. The composition or premix contains 1 to 100 parts by mass of 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine and/or 1 to 100 parts by mass of 2,4-diamino-5-(3,4-dimethoxybenzyl)pyrimidine as well as 1 to 100 parts by mass of 2,6-dimethoxy-4-sulfanilamidopyrimidine or a pharmaceutically acceptable salt thereof and 1 to 100 parts by mass of 8-hydroxyquinoline or a pharmaceutically acceptable acid addition salt thereof optionally in admixture with carrier(s) and/or additive(s) commonly used in the pharmaceutical industry or for the preparation of premixes.Type: GrantFiled: February 22, 1988Date of Patent: October 3, 1989Assignee: EGIS GyogyszergvarInventors: Karoly Magyar, Janos Varga, Ferenc Simon, Hedvig Szauder nee Lauko, Pal Fekete, Attila Romvary, Janos Egri, Katalin Zukovics nae Someg
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Patent number: 4814174Abstract: The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier.The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 .mu.m with a high-energy irradiation in a dose of 1-15 Mrad--preferably with electrone radiation--and thereafter stretched at 80.degree.-90.degree. C. to a thickness of 2-200 .mu.m.The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.Type: GrantFiled: September 28, 1987Date of Patent: March 21, 1989Assignees: Egis Gyogyszergyar, Muanyagipari Kutato IntezetInventors: Iren Barta, Pal Fekete, Laszlo Pallos, Gabor Kovacs, Lajos Mahr
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Patent number: 4774090Abstract: The invention relates to a microencapsulated insecticidal composition containing isopropyl (2E,4E)-3,7,11-trimethyl-11-methoxy-2,4-dodecaidenoate which comprises 45-95% by weight of isopropyl (2E,4E)-3,7,11-trimethyl-11-methoxy-2,4-dodecadenoate as active ingredient, 1-15% by weight of butyl hydroxy toluene and 5-40% by weight of activated charcoal, in the form of powdery microcapsules having a grain size of 1-300 .mu.m and coated with a hydroxypropyl methyl cellulose phthalate or cellulose acetate phthalate polymer.The advantage of the microencapsulated insectidical composition according to the present invention resides in the increased stability.Type: GrantFiled: December 2, 1983Date of Patent: September 27, 1988Assignee: Egyt Gyogyszervegyeszeti GYARInventors: Pal Fekete, Karoly Magyar, Anna Mayer nee Almasi, Jozsef Kelemen, Katalin Toth
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Patent number: 4748023Abstract: The invention relates to a process for the preparation of sustained release solid pharmaceutical compositions having an active ingredient content of at least 80% and possessing a structure which loosens in aqueous medium but does not disintegrate to discrete particles within 4 hours which comprises coating the particles of the active ingredient in a liquid medium with a water insoluble polymer--preferably with an ethyl cellulose polymer film--and thereafter admixing the coated crystals with at least one disintegrating agent being capable of swelling in aqueous medium and other auxiliary agents conventionally used in pharmaceutical industry and pressing the mixture into tablets.The advantage of the process of the present invention is that it is readily feasible with a very wide range of active ingredients and provides sustained release tablets having a high active ingredient content.Type: GrantFiled: August 27, 1984Date of Patent: May 31, 1988Assignee: EGYT Gyogyszervegyeszeti GyarInventors: Eva Tamas, Pal Fekete, Tibor Kovacs, Denes Bezzegh, Ilona Bor nee Baumgartner, Zoltan Toth, Katalin Zukovics nee Sumeg
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Patent number: 4740228Abstract: The invention relates to new plant growth regulating compositions, which contain as active agent 0.001 to 95% by weight of one or more compound(s) of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each represent hydrogen atom, a C.sub.1-5 alkyl group, a C.sub.5-7 cycloalkyl group, an aryl group, a halogen-substituted aryl group, an aralkyl group, a C.sub.2-5 alkenyl group or a C.sub.2-5 alkynyl group, orR.sup.1 and R.sup.2 form, together with the adjacent nitrogen atom, a morpholino, pyrrolidino, piperidino or perhydroazepinyl group, andR.sup.3 stands for hydrogen or a C.sub.1-5 alkyl group,together with an inert, solid, liquid and/or gaseous carrier or diluent, and optionally one or more additives, such as surfactants or other substances of plant biological activity.The compounds of the general formula (I) in which R.sup.1 is hydrogen and R.sup.2 stands for hydrogen, C.sub.1-3 alkyl, aralkyl or C.sub.3-5 alkenyl group, furthermore in which R.sup.1 and R.sup.3 are hydrogen and R.sup.Type: GrantFiled: January 10, 1984Date of Patent: April 26, 1988Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Attila Kis-Tamas, Ferenc Jurak, Zoltan Vig, Pal Fekete, Judit Kulcsar
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Patent number: 4647599Abstract: The invention provides a method for preparing sustained release tablets comprising a hydrophilic polymer matrix, which amounts to at least 10% by weight of the composition, consisting of a 5:1-1:5 weight to weight ratio mixture of a VP-VA copolymer and of an acrylic acid homopolymer, cross-linked with polyallyl saccharose.The method of manufacturing of sustained release tablets according to the invention can be accomplished in two ways: either by manufacturing the granulate containing the active ingredient, or by supplementing the matrix granulate containing no active ingredient with the suitable amount of the active ingredient.The latter variant involves the advantage of a possible separation of large-scale manufacturing of pharmacons and that of a generally applicable retardizing system, the composition and, consequently, the retardizing ability of which can optionally be modified in accordance with the properties of the active ingredient(s) to be formulated.Type: GrantFiled: November 9, 1984Date of Patent: March 3, 1987Assignee: Egyt Gyogyszervegyeszeti CyarInventors: Denes Bezzegh, Pal Fekete, Zoltan Toth, Ilona Bor, Erzsebet Fellner