Patents by Inventor Pal Ivan

Pal Ivan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 5-(2-bromovinyl)-uridine
    Patent number: 4544740
    Abstract: The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, ##STR1## wherein R.sup.1 stands for a hydrogen atom, C.sub.1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C.sub.1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, ##STR2## wherein R is identical with R.sup.1, except where R.sup.1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V ##STR3## and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.
    Type: Grant
    Filed: September 7, 1982
    Date of Patent: October 1, 1985
    Assignee: Egyt Gyogyszervegyeszeti Gyar
    Inventors: Anna Szabolcs nee Borbas, Laszlo tvos, Janos Sagi, Attila Szemzo, Maria Peredy nee Kajtar, Istvan Horvath, Istvan Koczka, Csilla Rethati, Pal Ivan, Ildiko Fritzsche nee Lukacs, Janos Nagy