Publication number: 20190256498
Abstract: The present invention provides novel crystalline form L1 of daclatasvir dihydrochloride wherein the diffraction peaks at 5.35, 6.04, 6.76, 8.65, 9.21, 10.35, 10.32, 10.75, 11.04, 11.66, 12.95, 13.56, 16.06, 18.11, 20.58, 22.18, 23.27±0.2 degree two theta in an X-ray diffraction pattern. The present invention provides novel crystalline form L2 of daclatasvir dihydrochloride wherein the diffraction peaks at 8.27, 9.54, 11.06, 13.61, 15.34, 19.01, 22.26, 23.24, 24.73, 25.35±0.2 degree two theta in an X-ray diffraction pattern. The present invention further provides process for preparation of crystalline forms L1 and L2 of daclatasvir dihydrochloride.
Type:
Application
Filed:
July 7, 2017
Publication date:
August 22, 2019
Inventors:
Palash SANPHUI, Radhakrishna Bhikaji SHIVDAVKAR, Gurvinder Pal SINGH, Purna Chandra RAY, Girij Pal SINGH, Vikas Ashokrao SADAPHAL, Lalitkumar Dilipising RAJPUT, Hemraj Mahadeorao LANDE