Patents by Inventor Pallab Banerjee
Pallab Banerjee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8999661Abstract: The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective delivery of agents to cells undergoing apoptosis or necrosis. The compounds and methods are based on conjugates formed with a dehydrogenase such as lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, and malate dehydrogenase. The compounds and methods are useful in the diagnosis and treatment of conditions characterized by apoptosis, including cancer, cardiac disease, neurologic disease including stroke, and autoimmunity. The compounds and methods offer distinct advantages over corresponding compounds and methods based on Annexin V. Also provided are methods for screening for compounds that modulate, i.e., inhibit or promote, apoptosis.Type: GrantFiled: July 29, 2009Date of Patent: April 7, 2015Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Andrew Kung, Pallab Banerjee
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Patent number: 8562836Abstract: The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.Type: GrantFiled: November 30, 2010Date of Patent: October 22, 2013Assignee: Massachusetts Institute of TechnologyInventors: Jonathan F. Hester, Pallab Banerjee, Ariya Akthakul, Glenn C. Mailand
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Publication number: 20110168630Abstract: The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.Type: ApplicationFiled: November 30, 2010Publication date: July 14, 2011Applicant: Massachusetts Institute of TechnologyInventors: Anne M. Mayes, Jonathan F. Hester, Pallab Banerjee, Ariya Akthakul, Glenn C. Mailand
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Patent number: 7868087Abstract: The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.Type: GrantFiled: September 29, 2006Date of Patent: January 11, 2011Assignee: Massachusetts Institute of TechnologyInventors: Anne M. Mayes, Jonathan F. Hester, Pallab Banerjee, Ariya Akthakul
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Publication number: 20100034800Abstract: The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective delivery of agents to cells undergoing apoptosis or necrosis. The compounds and methods are based on conjugates formed with a dehydrogenase such as lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, and malate dehydrogenase. The compounds and methods are useful in the diagnosis and treatment of conditions characterized by apoptosis, including cancer, cardiac disease, neurologic disease including stroke, and autoimmunity. The compounds and methods offer distinct advantages over corresponding compounds and methods based on Annexin V. Also provided are methods for screening for compounds that modulate, i.e., inhibit or promote, apoptosis.Type: ApplicationFiled: July 29, 2009Publication date: February 11, 2010Applicant: Dana-Farber Cancer Institute, Inc.Inventors: Andrew Kung, Pallab Banerjee
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Publication number: 20070219322Abstract: The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.Type: ApplicationFiled: September 29, 2006Publication date: September 20, 2007Applicant: Massachusetts Institute of TechnologyInventors: Anne Mayes, Jonathan Hester, Pallab Banerjee, Ariya Akthakul
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Patent number: 7153905Abstract: Hyperbranched dendron (HD) polymers are synthesized using low molecular weight polyethyleneimine (BPEI-L) as a core and used for gene delivery. The obtained polymers display low toxicity and efficient gene delivery at low nitrogen-to-phosphate (N/P) ratios. Using successive attachment of ethyleneimine moieties to a PEI core, the polymer has a lower relative ratio of linear-to-branched structures than in the core PEI. The more extensive branching enables the polymer to condense plasmid DNA into nanostructure complexes with a size of less than or equal to about 100 nm. The complexes are stable and efficient in transfecting cells in the presence of serum. Bioluminescent imaging of in vivo gene expression using a luciferase reporter gene performed in live mice showed gene expression in the liver and in submandibular lymph nodes.Type: GrantFiled: March 22, 2004Date of Patent: December 26, 2006Assignee: The General Hospital CorporationInventors: Pallab Banerjee, Wilfried Reichardt, Ralph Weissleder, Alexei Bogdanov
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Publication number: 20060258804Abstract: Hyperbranched dendron (HD) polymers are synthesized using low molecular weight polyethyleneimine (BPEI-L) as a core and used for gene delivery. The obtained polymers display low toxicity and efficient gene delivery at low nitrogen-to-phosphate (N/P) ratios. Using successive attachment of ethyleneimine moieties to a PEI core, the polymer has a lower relative ratio of linear-to-branched structures than in the core PEI. The more extensive branching enables the polymer to condense plasmid DNA into nanostructure complexes with a size of less than or equal to about 100 nm. The complexes are stable and efficient in transfecting cells in the presence of serum. Bioluminescent imaging of in vivo gene expression using a luciferase reporter gene performed in live mice showed gene expression in the liver and in submandibular lymph nodes.Type: ApplicationFiled: May 11, 2006Publication date: November 16, 2006Applicant: THE GENERAL HOSPITAL CORPORATION d/b/a MASSACHUSETTS GENERAL HOSPITALInventors: Pallab Banerjee, Wilfried Reichardt, Ralph Weissleder, Alexei Bogdanov
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Publication number: 20050079149Abstract: Hyperbranched dendron (HD) polymers are synthesized using low molecular weight polyethyleneimine (BPEI-L) as a core and used for gene delivery. The obtained polymers display low toxicity and efficient gene delivery at low nitrogen-to-phosphate (N/P) ratios. Using successive attachment of ethyleneimine moieties to a PEI core, the polymer has a lower relative ratio of linear-to-branched structures than in the core PEI. The more extensive branching enables the polymer to condense plasmid DNA into nanostructure complexes with a size of less than or equal to about 100 nm. The complexes are stable and efficient in transfecting cells in the presence of serum. Bioluminescent imaging of in vivo gene expression using a luciferase reporter gene performed in live mice showed gene expression in the liver and in submandibular lymph nodes.Type: ApplicationFiled: March 22, 2004Publication date: April 14, 2005Inventors: Pallab Banerjee, Wilfried Reichardt, Ralph Weissleder, Alexei Bogdanov
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Patent number: 6632883Abstract: The present invention relates to block copolymer compositions capable of being processed by the application of pressure. The invention also provides methods for predicting phase diagrams of polymer blends and block copolymers, particularly block copolymers comprising hard and soft blocks having properties described herein. The methods of the invention allow prediction of polymeric systems which can be processed under conditions that do not promote polymer degradation.Type: GrantFiled: February 16, 2001Date of Patent: October 14, 2003Assignees: Massachusetts Institute of Technology, University of MassachusettsInventors: Anne M. Mayes, Anne Valerie Ruzette, Thomas P. Russell, Pallab Banerjee
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Publication number: 20020147282Abstract: The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.Type: ApplicationFiled: September 12, 2001Publication date: October 10, 2002Inventors: Anne M. Mayes, Jonathan F. Hester, Pallab Banerjee, Ariya Akthakul
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Patent number: 6399700Abstract: Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents.Type: GrantFiled: March 26, 2001Date of Patent: June 4, 2002Assignee: Massachusetts Institute of TechnologyInventors: Anne M. Mayes, Linda G. Griffith, Darrell J. Irvine, Pallab Banerjee, Terry D. Johnson
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Publication number: 20020042480Abstract: The present invention relates to block copolymer compositions capable of being processed by the application of pressure. The invention also provides methods for predicting phase diagrams of polymer blends and block copolymers, particularly block copolymers comprising hard and soft blocks having properties described herein. The methods of the invention allow prediction of polymeric systems which can be processed under conditions that do not promote polymer degradation.Type: ApplicationFiled: February 16, 2001Publication date: April 11, 2002Inventors: Anne M. Mayes, Anne-Valerie Ruzette, Thomas P. Russell, Pallab Banerjee
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Patent number: 6361901Abstract: A polymer electrolyte includes a self-doped microphase separated block copolymer including at least one ionically conductive block and at least one second block that is immiscible in the ionically conductive block, an anion immobilized on the polymer electrolyte and a cationic species. The ionically conductive block provides a continuous ionically conductive pathway through the electrolyte. The electrolyte may be used as an electrolyte in an electrochemical cell.Type: GrantFiled: July 23, 1999Date of Patent: March 26, 2002Assignee: Massachusetts Institute of TechnologyInventors: Anne M. Mayes, Donald R. Sadoway, Pallab Banerjee, Philip Soo, Biying Huang
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Publication number: 20010027237Abstract: Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents.Type: ApplicationFiled: March 26, 2001Publication date: October 4, 2001Inventors: Anne M. Mayes, Linda G. Griffith, Darrell J. Irvine, Pallab Banerjee, Terry D. Johnson
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Patent number: 6207749Abstract: Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents.Type: GrantFiled: August 8, 2000Date of Patent: March 27, 2001Assignee: Massachusetts Institute of TechnologyInventors: Anne M. Mayes, Linda G. Griffith, Darrell J. Irvine, Pallab Banerjee, Terry D. Johnson
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Patent number: 6150459Abstract: Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents.Type: GrantFiled: April 13, 1999Date of Patent: November 21, 2000Assignee: Massachusetts Institute of TechnologyInventors: Anne M. Mayes, Linda G. Griffith, Darrell J. Irvine, Pallab Banerjee, Terry D. Johnson