Patents by Inventor Pallav Kosuri

Pallav Kosuri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Force-clamp spectrometer with functionalized cantilever tip
    Patent number: 9880088
    Abstract: The disclosed subject matter relates to a force-clamp spectrometer that enables operation in constant force mode and allows for automated data acquisition and analysis, using feedback electronics and software. The disclosed subject matter also relates to methods of using the force-clamp spectrometer for the measurement of the dynamics of chemical reactions. The methods may include, but are not limited to, the measurement of the dynamics of substrate folding and unfolding, as well as bond cleavage and bond formation.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: January 30, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Julio M. Fernandez, Raul Perez-Jimenez, Pallav Kosuri
  • ANCESTRAL PROTEINS
    Publication number: 20180016562
    Abstract: The invention provides a method tar increasing the stability and/or activity of a polypeptide at low pH and/or elevated temperatures The invention farther provides a method for increasing the melting temperature of a polypeptide. Also provided are paleoenzymologically reconstructed thioredoxin polypeptides having activity at higher temperatures and/or lower pH than extant thioredoxin polypeptides, as well as paleoenzymologically reconstructed thioredoxin polypeptides having higher melting temperatures than extant thioredoxin polypepetides.
    Type: Application
    Filed: July 27, 2017
    Publication date: January 18, 2018
    Inventors: Julio M. FERNANDEZ, Raul PEREZ-JIMENEZ, Eric GAUCHER, Pallav KOSURI
  • ANCESTRAL PROTEINS
    Publication number: 20130252307
    Abstract: The invention provides a method for increasing the stability and/or activity of a polypeptide at low pH and/or elevated temperatures. The invention further provides a method for increasing the melting temperature of a polypeptide. Also provided are paleoenzymologically reconstructed thioredoxin polypeptides having activity at higher temperatures and/or lower pH than extant thioredoxin polypepetides, as well as paleoenzymologically reconstructed thioredoxin polypeptides having higher melting temperatures than extant thioredoxin polypepetides.
    Type: Application
    Filed: July 15, 2011
    Publication date: September 26, 2013
    Applicant: GEORGIA TECH RESEARCH CORPORATION
    Inventors: Julio M. Fernandez, Raul Perez-Jimenez, Eric Gaucher, Pallav Kosuri