Patents by Inventor Pallavi Bhatta
Pallavi Bhatta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220267476Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.Type: ApplicationFiled: May 2, 2022Publication date: August 25, 2022Inventors: Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 11345760Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.Type: GrantFiled: June 25, 2015Date of Patent: May 31, 2022Assignee: UCB BIOPHARMA SRLInventors: Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 11286312Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.Type: GrantFiled: December 1, 2016Date of Patent: March 29, 2022Assignee: UCB BIOPHARMA SRLInventors: Pallavi Bhatta, Laura Starkie, Michael John Wright
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Publication number: 20210324111Abstract: The present invention provides a multispecific antibody molecule comprising at least two binding domains each with a variable heavy region VH and a variable light region VL, wherein each binding domain is specific for an antigen and comprises 6 CDRs, characterised in that at least one binding domain comprises a variable heavy region, VHA, having a framework comprising valine at position (5), lysine at position (13), alanine at position (24) and threonine at position (96) with the proviso that CDRH3 in VHA is other than RYYSAMPFAY (SEQ ID NO:29) and a variable light region, VLA, having a framework comprising leucine at position (11) and glutamine at position (103).Type: ApplicationFiled: December 18, 2017Publication date: October 21, 2021Inventors: Pallavi Bhatta, David Paul Humphreys
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Patent number: 11091542Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: December 14, 2016Date of Patent: August 17, 2021Assignee: UCB BIOPHARMA SRLInventors: Ralph Adams, Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys, Diane Marshall, Daniel John Lightwood
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Publication number: 20200291104Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: December 14, 2016Publication date: September 17, 2020Inventors: Ralph Adams, Pallavi Bhatta, Emma Dave, Sam Philip Heywood, Dave Paul Humphreys, Diane Marshall, Daniel John Lightwood
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Publication number: 20200277366Abstract: The invention relates to multi-specific antibody molecules having specificity for TNF alpha, IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: December 14, 2016Publication date: September 3, 2020Applicant: UCB Biopharma SPRLInventors: Ralph ADAMS, Pallavi BHATTA, Emma DAVE, Sam Philip HEYWOOD, David Taul HUMPHERYS, Diane MARSHALL, Stevan Graham SHAW, Daniel John LIGHTWOOD
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Publication number: 20180346603Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.Type: ApplicationFiled: December 1, 2016Publication date: December 6, 2018Inventors: Pallavi BHATTA, Laura STARKIE, Michael John WRIGHT
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Patent number: 10023631Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.Type: GrantFiled: October 27, 2017Date of Patent: July 17, 2018Assignee: UCB Biopharma SPRLInventors: Ralph Adams, Pallavi Bhatta, Sam Philip Heywood, David Paul Humphreys
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Publication number: 20180134774Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.Type: ApplicationFiled: October 27, 2017Publication date: May 17, 2018Applicant: UCB Biopharma SPRLInventors: Ralph ADAMS, Pallavi BHATTA, Sam Philip HEYWOOD, David Paul HUMPHREYS
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Publication number: 20180127498Abstract: The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.Type: ApplicationFiled: May 9, 2016Publication date: May 10, 2018Applicant: UCB Biopharma SPRLInventors: Pallavi BHATTA, Emma DAVE, Sam Philip HEYWOOD, David Paul HUMPHREYS, Bryan John SMITH
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Patent number: 9873735Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: April 27, 2015Date of Patent: January 23, 2018Assignee: UCB Biopharma SprlInventors: Ralph Adams, Pallavi Bhatta, Sam Philip Heywood, David Paul Humphreys
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Patent number: 9803004Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.Type: GrantFiled: November 9, 2012Date of Patent: October 31, 2017Assignee: UCB Biopharma SPRLInventors: Ralph Adams, Pallavi Bhatta, Sam Philip Heywood, David Paul Humphreys
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Publication number: 20170204200Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.Type: ApplicationFiled: June 25, 2015Publication date: July 20, 2017Inventors: Pallavi BHATTA, Emma DAVE, Sam Philip HEYWOOD, David Paul HUMPHREYS
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Publication number: 20170198062Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-CH2-CH3-X-(V1)p; and b) a polypeptide chain of formula (II): VL-CL-Y-(V2)q and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multi-specific antibody molecule of the present disclosure from a host cell.Type: ApplicationFiled: June 25, 2015Publication date: July 13, 2017Applicant: UCB BIOPHARM SPRLInventors: Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Publication number: 20160031974Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: April 27, 2015Publication date: February 4, 2016Inventors: Ralph Adams, Pallavi Bhatta, Sam Philip Heywood, David Paul Humphreys
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Patent number: 9040048Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: November 8, 2012Date of Patent: May 26, 2015Assignee: UCB Biopharma SPRLInventors: Ralph Adams, Pallavi Bhatta, Sam Philip Heywood, David Paul Humphreys
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Publication number: 20130243772Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: November 8, 2012Publication date: September 19, 2013Applicant: UCB Pharma S.A.Inventors: Ralph Adams, Pallavi Bhatta, Sam Phillip Heywood, David Paul Humphreys