Abstract: A backup management system may include a data management server, a warm-tier data store, and a cold-tier data store. Snapshots may be captured from various client devices. A data block stored in the warm-tier data store may be referenced by multiple backup snapshots and/or referenced by one or more users. When a data block's total reference count is equal to the cold reference count or equal to or less than a threshold total reference count, the data management server may determine that the data block is ready to be migrated to the cold-tier data store. The data management server may send the data block into a candidate queue. In the queue, data blocks with similar retention periods or similar expected restoration may be grouped as a unit. The unit may be transmitted to the cold-tier data store in a single write request.

Abstract: A file system and a related method are presented. The file system includes an object storage configured to store file data for one or more files and a plurality of namespace entries corresponding to file data and/or metadata of the one or more files as one or more objects. Each namespace entry of the plurality of namespace entries includes an operation type conducted on the file data and/or metadata captured in a particular snapshot and a version number corresponding to the particular snapshot. The file system further includes an indexing system configured to generate the plurality of namespace entries; store the plurality of namespace entries as one or more objects in the object storage; and identify, in response to a search query, one or more files for retrieval from the object storage based on a list of the plurality of namespace entries sorted on the version numbers.

Abstract: The present invention provides triazole carboxylic acids and related compounds, as well as pharmaceutically acceptable salts thereof, which are useful as glycolate oxidase inhibitors. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

Abstract: A data restoration system including a data management server. The data management server receives one or more data restoration requests for restoring a plurality of data blocks. The data management server determines, based on metadata associated with the data blocks, a first subset of warm data blocks corresponding to warm-tier data and a second subset of cold data blocks corresponding to cold-tier data. The data management server retrieves the warm data blocks in the first subset and restores the warm data blocks in the first subset. The data management server groups the cold data blocks based in part on storage times of the cold data blocks to generate a plurality of cold-tier data retrieval requests. The data management server retrieves the cold data blocks by batches, each batch corresponding to one of the cold-tier data retrieval requests. The data management server restores the cold data blocks in the second subset.

Abstract: The present invention provides triazole carboxylic acids and related compounds, as well as pharmaceutically acceptable salts thereof, which are useful as glycolate oxidase inhibitors. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

Abstract: A data restoration system including a data management server. The data management server receives one or more data restoration requests for restoring a plurality of data blocks. The data management server determines, based on metadata associated with the data blocks, a first subset of warm data blocks corresponding to warm-tier data and a second subset of cold data blocks corresponding to cold-tier data. The data management server retrieves the warm data blocks in the first subset and restores the warm data blocks in the first subset. The data management server groups the cold data blocks based in part on storage times of the cold data blocks to generate a plurality of cold-tier data retrieval requests. The data management server retrieves the cold data blocks by batches, each batch corresponding to one of the cold-tier data retrieval requests. The data management server restores the cold data blocks in the second subset.

Abstract: The present invention provides triazole carboxylic acids and related compounds, as well as pharmaceutically acceptable salts thereof, which are useful as glycolate oxidase inhibitors. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

Abstract: System for delivering an event journal during a back-up session in a distributed file system is presented. The system includes an event intake module, a load balancer, a plurality of object creation modules, a journal manager, and a journal service module. Each object creation module of the plurality of object creation modules further includes an ingestor and a drainer. A related method is also presented. The system and method provide for reliable and time-ordered delivery of events in the event journal.

Abstract: A backup management system may include a data management server, a warm-tier data store, and a cold-tier data store. Snapshots may be captured from various client devices. A data block stored in the warm-tier data store may be referenced by multiple backup snapshots and/or referenced by one or more users. When a data block's total reference count is equal to the cold reference count or equal to or less than a threshold total reference count, the data management server may determine that the data block is ready to be migrated to the cold-tier data store. The data management server may send the data block into a candidate queue. In the queue, data blocks with similar retention periods or similar expected restoration may be grouped as a unit. The unit may be transmitted to the cold-tier data store in a single write request.