Patents by Inventor Paloma H. Giangrande

Paloma H. Giangrande has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid aptamers to treat histone-induced disease states
    Patent number: 11680079
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: June 20, 2023
    Assignees: University of Iowa Research Foundation, The United States Government As Represented By The Department of Veteran Affairs
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • EPH2A APTAMER AND USES THEREOF
    Publication number: 20220251561
    Abstract: The present invention belongs to the field of genetic therapy. In particular, the invention refers to EphA2 specific RNA-based constructs, which are useful for the treatment, prevention and diagnosis of EphA2 expressing cancers.
    Type: Application
    Filed: June 2, 2020
    Publication date: August 11, 2022
    Inventors: Óscar MARTINEZ TIRADO, Paloma H. GIANGRANDE
  • Nucleic Acid Aptamers to Treat Histone-Induced Disease States
    Publication number: 20210017217
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: April 13, 2020
    Publication date: January 21, 2021
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • Nucleic acid aptamers to treat histone-induced disease states
    Patent number: 10633410
    Abstract: The present invention relates to methods of using optimized aptamers. In certain embodiments, the present invention provides a method for treating a subject having or being disposed to having a histone-induced injury or disease comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (i) a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA; or (ii) a conjugate comprising a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA, wherein the nucleic acid molecule is linked to a therapeutic molecule.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: April 28, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • OLIGONUCLEOTIDE-BASED PROBES FOR DETECTION OF CIRCULATING TUMOR CELL NUCLEASES
    Publication number: 20180282783
    Abstract: The present invention relates to a rapid detection of circulating tumor cell (CTC)-associated nuclease activity with chemically modified nuclease substrate probes and compositions useful in detection assays.
    Type: Application
    Filed: April 25, 2016
    Publication date: October 4, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paloma H. Giangrande, James O. McNamara, David D. Dickey, Howard Ozer, Sven Kruspe
  • NUCLEIC ACID APTAMERS TO TREAT HISTONE-INDUCED DISEASE STATES
    Publication number: 20180134746
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: December 22, 2015
    Publication date: May 17, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • HER2 nucleic acid aptamers
    Patent number: 9163242
    Abstract: The present invention relates to optimized HER2 aptamers and methods of using these aptamers.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: October 20, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, James O. McNamara, Kristina W. Thiel, William Thiel, William M. Rockey
  • NUCLEIC ACID APTAMERS
    Publication number: 20140148503
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: July 18, 2012
    Publication date: May 29, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, William M. Rockey
  • Nucleic acid aptamers
    Patent number: 8685937
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: April 1, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, James O. McNamara, Anton P. McCaffrey
  • HER2 NUCLEIC ACID APTAMERS
    Publication number: 20130129719
    Abstract: The present invention relates to optimized HER2 aptamers and methods of using these aptamers.
    Type: Application
    Filed: April 27, 2011
    Publication date: May 23, 2013
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paloma H. Giangrande, James O. McNamara, Kristina W. Thiel, William Thiel, William M. Rockey
  • Delivery method
    Publication number: 20120124683
    Abstract: The present invention relates, in general, to siRNA and, in particular, to a method of effecting targeted delivery of siRNAs and to compounds suitable for use in such a method.
    Type: Application
    Filed: June 29, 2011
    Publication date: May 17, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Bruce A. Sullenger, Paloma H. Giangrande, James McNamara
  • NUCLEIC ACID APTAMERS
    Publication number: 20120014875
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: August 6, 2009
    Publication date: January 19, 2012
    Applicant: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, James O. McNamara, Anton P. McCaffrey
  • Delivery Method
    Publication number: 20100324113
    Abstract: The present invention relates, in general, to siRNA and, in particular, to a method of effecting targeted delivery of siRNAs and to compounds suitable for use in such a method.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 23, 2010
    Inventors: Bruce A. Sullenger, Paloma H. Giangrande, James McNamara
  • Molecular targeting agents
    Publication number: 20100234450
    Abstract: The present invention relates to aptamer conjugates comprising a metal chelating group and to methods of using these aptamers.
    Type: Application
    Filed: March 16, 2010
    Publication date: September 16, 2010
    Inventors: Michael K. Schultz, James O. McNamara, Paloma H. Giangrande