Patents by Inventor Pamela Brown

Pamela Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10544444
    Abstract: Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: January 28, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Michael S. VanNieuwenhze, Edward Hall, Erkin Kuru, Pamela Brown, Srinivas Tekkam, Velocity Hughes, Yves Brun
  • Patent number: 10407467
    Abstract: Described are compounds of formula (I) for use in combination treatment with a second active agent, such as rifampicin, for example for treatment of a microbial infection. The compound of formula (I) is a polymyxin compound is: where the groups -A-, —R1, —R2, —R3, —R4, —R5, —R6, —R7, —R8, and —X— are described in detail within the description.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: September 10, 2019
    Assignee: NEW PHARMA LICENCE HOLDINGS LIMITED
    Inventors: Pamela Brown, Michael Dawson, Mona Simonovic, Steven Boakes, Esther Duperchy
  • Publication number: 20190024135
    Abstract: Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 24, 2019
    Inventors: Michael S. Van Nieuwenhze, Edward Hall, Erkin Kuru, Pamela Brown, Srinivas Tekkam, Velocity Hughes, Yves Brun
  • Publication number: 20180142038
    Abstract: A new class of antibodies having specificity for glycoproteins are described. The antibodies are shown to bind sensitively and specifically to mannosylated proteins, such as proteins produced by fungi. Assays using these anti-glycoprotein antibodies for monitoring the presence of glycoproteins in a sample are provided. Such methods can be used to monitor methods for production and/or purification of desired polypeptides, which may be used to modify process parameters to modify (e.g., decrease or increase) the amount of glycosylated polypeptide produced and/or present in the purified product. Also provided are methods of using the subject antibodies for detecting the level of expression and secretion of a polypeptide, and methods of using the subject antibodies to purify or deplete a glycoprotein from a sample. In exemplary embodiments, the desired polypeptide may be a multi-subunit protein, such as an antibody, which may be produced in a yeast, such as Pichia pastoris.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 24, 2018
    Applicant: ALDER BIOPHARMACEUTICALS, INC. a/b/a ALDERBIO HOLDINGS LLC
    Inventors: Pamela BROWN, Geoffrey F. LEE, Benjamin DUTZAR, Jenny A. MULLIGAN, Daniel S. ALLISON, Ethan W. OJALA, Amarjeet SINGH
  • Publication number: 20180030092
    Abstract: The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided.
    Type: Application
    Filed: November 26, 2015
    Publication date: February 1, 2018
    Inventors: Pamela Brown, Michael Dawson, Mona Simonovic, Steven Boakes, Esther Duperchy, Steven James Stanway, Antoinette Wilson, Stephen Frederick Moss
  • Publication number: 20170073373
    Abstract: Provided are compounds of formula (III), and the use of compounds of formula (III) in methods of treatment, such as methods of treating a microbial infection. The compounds of formula (III) is: where —R15 is an amino-containing group: and —R1, —R2, —R3, —R4, —R8, —RA, Q, —R16, —R17 are as described in further detail in the description.
    Type: Application
    Filed: March 11, 2015
    Publication date: March 16, 2017
    Inventors: Pamela Brown, Michael Dawson, Mona Simonovic, Steven Boakes, Esther Duperchy, Steven James Stanway, Antoinette Wilson, Stephen Frederick Moss
  • Publication number: 20160222061
    Abstract: Described are compounds of formula (I) for use in combination treatment with a second active agent, such as rifampicin, for example for treatment of a microbial infection. The compound of formula (I) is a polymyxin compound is: where the groups -A-, —R1, —R2, —R3, —R4, —R5, —R6, —R7, —R8, and —X— are described in detail within the description.
    Type: Application
    Filed: May 21, 2014
    Publication date: August 4, 2016
    Applicant: NEW PHARMA LICENCE HOLDINGS LIMITED
    Inventors: Pamela Brown, Michael Dawson, Mona Simonovic, Steven Boakes, Esther Duperchy
  • Patent number: 9234006
    Abstract: Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is —NHC(O)—, —C(O)—, —OC(O)—, —CH2— or —SO2—; R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkylyl). and the alkyl or cycloalkylyl bears one, two or three hydroxyl groups, or a —NR6R7 group, or one —NR6R7 group and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: January 12, 2016
    Assignees: Novacta Biosystems Limited, Cantab Anti-Infectives Limited
    Inventors: Mona Saadi, Esther Duperchy, Pamela Brown, Michael John Dawson, Sjoerd Nicolaas Wadman
  • Publication number: 20150191763
    Abstract: Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.
    Type: Application
    Filed: April 21, 2013
    Publication date: July 9, 2015
    Inventors: Michael Van Nieuwenhze, Edward Hall, Erkin Kuru, Pamela Brown, Srinivas Tekkam, Velocity Hughes, Yves Brun
  • Publication number: 20150031602
    Abstract: Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is —NHC(O)—, —C(O)—, —OC(O)—, —CH2— or —SO2—; R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkyl). and the alkyl or cycloalkyl bears one, two or three hydroxyl groups, or a —NR6R7 group, or one —NR6R7 group and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description.
    Type: Application
    Filed: November 16, 2012
    Publication date: January 29, 2015
    Applicants: CANTAB ANTI-INFECTIVES LIMITED, NOVACTA BIOSYSTEMS LIMITED
    Inventors: Mona Saadi, Esther Duperchy, Pamela Brown, Michael John Dawson, Sjoerd Nicolaas Wadman
  • Publication number: 20110009394
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials.
    Type: Application
    Filed: January 7, 2009
    Publication date: January 13, 2011
    Applicant: Glaxo Group Limited
    Inventors: Pamela Brown, Steven Dabbs, Alan Joseph Hennessy
  • Publication number: 20100087424
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials.
    Type: Application
    Filed: April 17, 2008
    Publication date: April 8, 2010
    Inventors: Pamela Brown, Steven Dabbs
  • Publication number: 20100056502
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials.
    Type: Application
    Filed: March 20, 2008
    Publication date: March 4, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Pamela Brown, Steven Dabbs, David Thomas Davies, Neil David Pearson
  • Publication number: 20070167495
    Abstract: Pleuromutilin compounds of the formula: are of use in antibacterial therapy.
    Type: Application
    Filed: April 6, 2004
    Publication date: July 19, 2007
    Applicant: GLAXOSMITHKLINE SERVICES UNLIMITED
    Inventors: Pamela Brown, Eric Hunt
  • Publication number: 20060041123
    Abstract: Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
    Type: Application
    Filed: December 17, 2003
    Publication date: February 23, 2006
    Inventors: Jeffrey Axten, Gerald Brooks, Pamela Brown, David Davies, Timothy Gallagher, Roger Markwell, William Miller, Neil Pearson, Mark Seefeld
  • Publication number: 20050020937
    Abstract: The invention provides methods and kits for collection of cervical/vaginal specimen. The specimen is collected for the purpose of detecting the presence or absence of etiological agents, e.g., bacterial or viral agents, including but not limited to human papilloma virus (HPV). The endocervical cells is not required for HPV testing or Pap smear. The methods and kits allow the self-sampling without the aid of trained medical personnel.
    Type: Application
    Filed: July 23, 2003
    Publication date: January 27, 2005
    Inventors: Eddie Reed, Barbara Ducatman, Timothy Tracy, A. Soisson, Pamela Brown
  • Patent number: 6320051
    Abstract: Compounds of formula (I) are inhibitors of the bacterial enzyme S aureus methionyl tRNA synthetase and are of use in treating bacterial infections.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: November 20, 2001
    Assignee: SmithKline Beecham plc
    Inventors: John Michael Berge, Pamela Brown, John Stephen Elder, Andrew Keith Forrest, Dieter Wolfgang Hamprecht, Richard Lewis Jarvest, David Jonathan McNair, Robert John Sheppard
  • Patent number: 4521337
    Abstract: A process for the preparation of a compound of the formulae (Ia) and/or (Ib): ##STR1## wherein R.sup.1 and R.sup.2 are independently substituted or unsubstituted hydrocarbon groups or are joined together so as to form a carbocyclic or heterocyclic ring, and R.sup.3 is a substituted or unsubstituted hydrocarbon group; which process comprises the ring-closing cyclization of a compound of the formula (II): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in relation to formulae (Ia) and (Ib).
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: June 4, 1985
    Assignee: Beecham Group p.l.c.
    Inventors: Robert Southgate, Pamela Brown
  • Patent number: 4477662
    Abstract: A process for the preparation of an antibacterially active compound of the formula (I): ##STR1## and salts and esters thereof wherein R.sup.1 and R.sup.2 independently are hydrogen or an organic group, and R.sup.3 is an organic group bonded via a carbon atom to the sulphur atom, which comprises reacting a compound of the formula (II): ##STR2## wherein R.sup.4 is an organic group different to R.sup.3 and R.sup.a is hydrogen or a carboxy-blocking group, with a thiol R.sup.3 SH or reactive derivative thereof. In addition certain compounds within the formula (II) are novel and useful antibacterial agents in their own right.
    Type: Grant
    Filed: February 3, 1982
    Date of Patent: October 16, 1984
    Assignee: Beecham Group p.l.c.
    Inventors: David F. Corbett, Pamela Brown nee Davis, Roger J. Ponsford
  • Patent number: 4410533
    Abstract: The present invention provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in-vivo hydrolyzable ester thereof wherein R.sup.1 is a hydrogen atom, an .alpha.-sulphonato-oxyethyl group, an .alpha.-sulphonato-oxypropyl group or is a group CR.sup.3 R.sup.4 R.sup.5 wherein R.sup.3 is a hydrogen atom or a hydroxy group; R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl group; and R.sup.5 is a hydrogen atom or a C.sub.1-6 alkyl group, a benzyl group, a phenyl group or is joined to R.sup.4 to form together with the carbon atom to which they are joined a carbocyclic ring of 5 to 7 carbon atoms; R.sup.2 is a pyrimidinyl group substituted by one two or three groups selected from nitro, halo, amino or substituted amino, and in addition may be optionally substituted by one or two C.sub.1-6 alkyl groups as the degree of substitution permits; and x is zero or one.These compounds are antibacterial agents. Their preparation and use are described.
    Type: Grant
    Filed: February 3, 1982
    Date of Patent: October 18, 1983
    Assignee: Beecham Group p.l.c.
    Inventors: Roger J. Ponsford, Pamela Brown, Steven Coulton