Abstract: Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof an effective amount of propofol or a propofol derivative having limited anesthetic properties. Methods of modulating HCN channel gating are also provided. Pharmaceutically acceptable compositions for, e.g., modulating HCN channel gating are further provided.

Abstract: Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof an effective amount of propofol or a propofol derivative having limited anesthetic properties. Methods of modulating HCN channel gating are also provided. Pharmaceutically acceptable compositions for, e.g., modulating HCN channel gating are further provided.

Abstract: This invention provides two methods for reducing, or inhibiting the onset of, pain in a subject. The first method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist, and (b) an opioid receptor agonist; wherein the ratio of nicotinic receptor agonist to opioid receptor agonist administered to the subject is less than 3:4 and greater than 1:100. The second method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist at a rate of less than 3 mg per three hour period; and (b) an opioid receptor agonist at a rate of less than 4 mg per three hour period. This invention also provides two compositions, a transdermal patch, and an article of manufacture for practicing the instant methods.

Abstract: Disclosed herein are compositions of nicotinic agonists, salts, hydrates, solvates or prodrugs thereof and therapeutic agents salts, hydrates, solvates or prodrugs thereof, pharmaceutical compositions thereof and methods of using these compositions and pharmaceutical compositions thereof to treat or prevent disease or pain in a subject. Also disclosed are methods of treating disease or pain or preventing disease or pain in a subject with nicotinic agonists, salts, hydrates, solvates or prodrugs thereof and therapeutic agents, salts, hydrates, solvates or prodrugs thereof.

Abstract: Disclosed herein are compositions and methods which treat or prevent pain in a subject. More specifically, disclosed herein are compositions of nicotinic agonists, salts, hydrates, solvates, prodrugs or metabolites thereof and opioid agonists salts, hydrates, solvates, prodrugs or metabolites thereof, pharmaceutical compositions thereof and methods of using these compositions and pharmaceutical compositions thereof to treat or prevent pain in a subject. Also disclosed are methods of treating or preventing pain in a subject with nicotinic agonists, salts, hydrates, solvates, prodrugs or metabolites thereof and opioid agonists, salts, hydrates, solvates, prodrugs or metabolites thereof.

Abstract: This invention provides a method for reducing hyperalgesia following a pain-inducing procedure being performed on a subject which comprises administering to the subject an anesthetic which is an antagonist of the subject's nicotinic acetylcholine receptor, in an amount effective to inhibit the subject's perception of pain during the pain-inducing procedure; then performing the pain-inducing procedure on the subject; and administering to the subject a hyperalgesia-reducing amount of an agonist of the subject's nicotinic acetylcholine receptor such that the subject's hyperalgesia following the procedure is reduced. This invention also provides related methods and articles of manufacture.