Patents by Inventor Pamela Heward

Pamela Heward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing alzheimer's disease and markers identified by set association
    Patent number: 8426130
    Abstract: The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: April 23, 2013
    Assignee: Translational Genomics Research Institute
    Inventors: Dietrich A. Stephan, Eric M. Reiman, Jennifer Webster, Andreas Papassotiropoulos, Pamela Heward
  • METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND MARKERS IDENTIFIED BY SET ASSOCIATION
    Publication number: 20090260092
    Abstract: The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 15, 2009
    Applicants: Translational Genomics Research Institute, Kronos Science Laboratory
    Inventors: Dietrich A. STEPHAN, Eric M. Reiman, Jennifer Webster, Christopher B. Heward, Pamela Heward, Andreas Papassotiropoulos
  • Methods of diagnosing alzheimer's disease and markers identified by set association
    Publication number: 20090249498
    Abstract: The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
    Type: Application
    Filed: April 21, 2008
    Publication date: October 1, 2009
    Applicants: TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, KRONOS SCIENCE LABORATORY
    Inventors: Dietrich A. Stephan, Eric M. Reiman, Jennifer Webster, Christopher B. Heward, Pamela Heward, Andreas Papassotiropoulos