Patents by Inventor Pamela Hunt

Pamela Hunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
    Patent number: 5795569
    Abstract: Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: August 18, 1998
    Assignee: Amgen Inc.
    Inventors: Timothy D. Bartley, Jakob M. Bogenberger, Robert A. Bosselman, Pamela Hunt, Olaf B. Kinstler, Babru B. Samal
  • Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
    Patent number: 5766581
    Abstract: Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. The MGDF proteins and derivatives are useful in methods for treating mammals to increase platelets and/or megakaryocytes. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: June 16, 1998
    Assignee: Amgen Inc.
    Inventors: Timothy D. Bartley, Jakob M. Bogenberger, Robert A. Bosselman, Pamela Hunt, Olaf B. Kinstler, Babru B. Samal
  • Methods for stimulating platelet production
    Patent number: 5498599
    Abstract: Disclosed is a method for increasing the number of platelets in a mammal, which comprises administering to the mammal a platelet number increasing effective amount of an unbound, preferably a soluble, MPL receptor.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: March 12, 1996
    Assignee: AMGEN Inc.
    Inventors: Esther S. Choi, Martha M. Hokom, Pamela Hunt, Janet L. Nichol
  • Transgenic animal models for thrombocytopenia
    Patent number: 5489743
    Abstract: Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: February 6, 1996
    Assignee: Amgen Inc.
    Inventors: Murray O. Robinson, Pamela Hunt, Robert A. Bosselman