Patents by Inventor Pamela J. Kaisaki

Pamela J. Kaisaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutations in the diabetes susceptibility genes hepatocyte nuclear factor (HNF) 1 alpha (alpha), HNF-1beta and HNF-4alpha
    Publication number: 20030224355
    Abstract: The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF1&agr; gene, MODY4 locus is the HNF1&bgr; and the MODY1 locus is the HNF4&agr; gene. The invention further relates to the discovery that analysis of mutations in the HNF1&agr;, HNF1&bgr; and HNF4&agr; genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF1&agr;, HNF1&bgr; and HNF4&agr; mutations can cause diabetes.
    Type: Application
    Filed: January 3, 2001
    Publication date: December 4, 2003
    Applicant: ARCH Development Corporation
    Inventors: Graeme I. Bell, Kazuya Yamagata, Naohisha Oda, Pamela J. Kaisaki, Hiroto Furuta, Yukio Horikawa, Stephan Menzel
  • Mutations in the diabetes susceptibility genes hepatocyte nuclear factor (HNF) 1 alpha (&agr;), HNF1&bgr; and HNF4&agr;
    Patent number: 6187533
    Abstract: The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF1&agr; gene, MODY4 locus is the HNF1&bgr; and the MODY1 locus is the HNF4&agr; gene. The invention further relates to the discovery that analysis of mutations in the HNF1&agr;, HNF1&bgr; and HNF4&agr; genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF1&agr;, HNF1&bgr; and HNF4&agr; mutations can cause diabetes.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: February 13, 2001
    Assignee: Arch Development Corporation
    Inventors: Graeme I. Bell, Kazuya Yamagata, Naohisha Oda, Pamela J. Kaisaki, Hiroto Furuta, Yukio Horikawa, Stephan Menzel