Patents by Inventor Pamela K. Foreman
Pamela K. Foreman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10378049Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: October 14, 2016Date of Patent: August 13, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew T. O'Keefe, Pamela K. Foreman
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Patent number: 10300140Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.Type: GrantFiled: July 27, 2012Date of Patent: May 28, 2019Assignee: I2 PHARMACEUTICALS, INC.Inventors: Ramesh R. Bhatt, Pamela K. Foreman, Lawrence C. Horowitz, Michael Horowitz, Medini Gore, Phil Kobel
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Publication number: 20190127482Abstract: The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular, the invention concerns Surrobody conjugates composed of an antibody heavy chain variable domain and a surrogate light chain, wherein the surrogate light chain and/or the antibody heavy chain variable domain is conjugated to a therapeutic or diagnostic agent.Type: ApplicationFiled: October 12, 2018Publication date: May 2, 2019Inventors: Lawrence C. HOROWITZ, Ramesh R. BHATT, Charles H. HANNUM, Pamela K. FOREMAN, Danying CAI, Medini GORE, Li XU, Phil KOBEL
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Patent number: 10227644Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: April 27, 2018Date of Patent: March 12, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew T. O'Keefe, Pamela K. Foreman
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Publication number: 20180245133Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: April 27, 2018Publication date: August 30, 2018Inventors: Matthew T. O'Keefe, Pamela K. Foreman
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Publication number: 20170101667Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: October 14, 2016Publication date: April 13, 2017Inventors: Matthew T. O'Keefe, Pamela K. Foreman
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Patent number: 9518299Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: December 2, 2014Date of Patent: December 13, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew T. O'Keefe, Pamela K. Foreman
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Publication number: 20160354486Abstract: The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular, the invention concerns Surrobody conjugates composed of an antibody heavy chain variable domain and a surrogate light chain, wherein the surrogate light chain and/or the antibody heavy chain variable domain is conjugated to a therapeutic or diagnostic agent.Type: ApplicationFiled: December 22, 2015Publication date: December 8, 2016Inventors: Lawrence C. Horowitz, Ramesh R. Bhatt, Charles H. Hannum, Pamela K. Foreman, Danying Cai, Medini Gore, Li Xu, Phil Kobel
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Publication number: 20150087550Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: December 2, 2014Publication date: March 26, 2015Inventors: Matthew T. O'Keefe, Pamela K. Foreman
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Publication number: 20150011736Abstract: The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular, the invention concerns Surrobody conjugates composed of an antibody heavy chain variable domain and a surrogate light chain, wherein the surrogate light chain and/or the antibody heavy chain variable domain is conjugated to a therapeutic or diagnostic agent.Type: ApplicationFiled: January 18, 2013Publication date: January 8, 2015Inventors: Lawrence C. Horowitz, Ramesh R. Bhatt, Charles H. Hannum, Pamela K. Foreman, Danying Cai, Medini Gore, Li Xu, Phil Kobel
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Patent number: 8906618Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: October 7, 2011Date of Patent: December 9, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew O'Keefe, Pamela K. Foreman
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Publication number: 20140308287Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.Type: ApplicationFiled: July 27, 2012Publication date: October 16, 2014Applicant: Sea Lane Biotechnologies, LLCInventors: Ramesh R. Bhatt, Pamela K. Foreman, Lawrence C. Horowitz, Michael Horowitz, Medini Gore, Phil Kobel
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Publication number: 20120077194Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: October 7, 2011Publication date: March 29, 2012Inventors: Matthew O'Keefe, Pamela K. Foreman
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Patent number: 8053185Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: October 20, 2009Date of Patent: November 8, 2011Assignee: Board of Trustees of The Leland Stanford Junior UniversityInventors: Matthew O'Keefe, Pamela K. Foreman
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Patent number: 7833719Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: December 20, 2007Date of Patent: November 16, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew O'Keefe, Pamela K. Foreman
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Publication number: 20100075330Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: October 20, 2009Publication date: March 25, 2010Inventors: Matthew O'Keefe, Pamela K. Foreman
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Patent number: 7604983Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: February 9, 2005Date of Patent: October 20, 2009Assignee: Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew O'Keefe, Pamela K. Foreman
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Patent number: 7332271Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: GrantFiled: February 20, 2001Date of Patent: February 19, 2008Assignee: Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew O'Keefe, Pamela K. Foreman
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Publication number: 20020151040Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: August 22, 2001Publication date: October 17, 2002Inventors: Matthew O' Keefe, Pamela K. Foreman
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Publication number: 20020072096Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.Type: ApplicationFiled: February 20, 2001Publication date: June 13, 2002Inventors: Matthew O'Keefe, Pamela K. Foreman