Patents by Inventor Pamela L. Larsen

Pamela L. Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutated adenovirus E1A gene for E1A promoter stimulation
    Patent number: 4920211
    Abstract: A functional mutated E1A gene of human adenovirus subgroup B:1 is provided which has a modified autorepression functional domain that is effective to express E1A products that stimulate without net repression of promoters controlling an E1A mutated gene.
    Type: Grant
    Filed: January 4, 1988
    Date of Patent: April 24, 1990
    Assignee: Vanderbilt University
    Inventors: Clark Tibbetts, Pamela L. Larsen
  • Transcriptional control element adapted for regulation of gene expression in animal cells
    Patent number: 4775630
    Abstract: A novel alteration of a viral DNA sequence, derived from a human adenovirus type 3 mutant (Ad3) designaed Ad3h15, provides a transcriptional control element which can be used to regulate expression of a selected gene in animal and human cells. The Ad3h15 control element blocks transcription of a controlled gene in the presence of the products of the Ad3 E1A gene, and amplifies transcription in the presence of type 5 (Ad5) adenovirus E1A gene products.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: October 4, 1988
    Assignee: Vanderbilt University
    Inventors: Clark Tibbetts, Pamela L. Larsen, Stephen N. Jones, Mary M. McGrane