Patents by Inventor Pamela M. Nagafuji

Pamela M. Nagafuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indenoisoquinolines as antineoplastic agents
    Patent number: 6509344
    Abstract: A number of indenoisoquinolines were prepared and evaluated for cytotoxicity in human cancer cell cultures and for activity versus topoisomerase I. The two most cytotoxic indenoisoquinolines proved to be cis-6-ethyl-5,6,12,13-tetrahydro-2,3-dimethoxy-8,9(methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline and cis-6-allyl-5,6,12,13-tetrahydro-2,3-dimethoxy-8,9-(methylenedioxy)-5,11-dioxo-(11H)indeno[1,2-c]isoquinoline. Two of the most potent topoisomerase I inhibitors were 6-(3-carboxy-1-propyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (26) and 6-ethyl-2,3-dimethoxy-8,9-(methylenedioxy)-11H-indeno[1,2-c]isoquinolinium chloride (27).
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: January 21, 2003
    Assignees: The United States of America as represented by the Department of Health and Human Services, Office of Technology Transfer National Institute of Health
    Inventors: Mark S. Cushman, Pamela M. Nagafuji, Muthusamy Jayaraman, Yves G. Pommier