Patents by Inventor Pamela Nuccitelli
Pamela Nuccitelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10695127Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: GrantFiled: April 15, 2019Date of Patent: June 30, 2020Assignee: PULSE BIOSCIENCES, INC.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Publication number: 20190239949Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: ApplicationFiled: April 15, 2019Publication date: August 8, 2019Applicant: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Patent number: 10307207Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: GrantFiled: July 19, 2018Date of Patent: June 4, 2019Assignee: PULSE BIOSCIENCES, INC.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Publication number: 20180318004Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: ApplicationFiled: July 19, 2018Publication date: November 8, 2018Applicant: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Patent number: 10058383Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: GrantFiled: August 7, 2017Date of Patent: August 28, 2018Assignee: PULSE BIOSCIENCES, INC.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Publication number: 20170360504Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: ApplicationFiled: August 7, 2017Publication date: December 21, 2017Applicant: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Patent number: 9724155Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: GrantFiled: November 30, 2015Date of Patent: August 8, 2017Assignee: PULSE BIOSCIENCES, INC.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Patent number: 9656066Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on size and type of a tumor to stimulate an immune response against the tumor and other tumors in a subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.Type: GrantFiled: July 22, 2015Date of Patent: May 23, 2017Assignee: PULSE BIOSCIENCES, INC.Inventors: Richard Lee Nuccitelli, Pamela Nuccitelli, Joanne Lum, Kaying Lui, Brian Athos, Mark Kreis, Zachary Mallon, Jon Berridge
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Publication number: 20160157932Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: ApplicationFiled: November 30, 2015Publication date: June 9, 2016Applicant: Electroblate, Inc.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Publication number: 20150320999Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on size and type of a tumor to stimulate an immune response against the tumor and other tumors in a subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.Type: ApplicationFiled: July 22, 2015Publication date: November 12, 2015Applicant: NanoBlate Corp.Inventors: Richard Lee Nuccitelli, Pamela Nuccitelli, Joanne Lum, Kaying Lui, Brian Athos, Mark Kreis, Zachary Mallon, Jon Berridge
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Patent number: 9101764Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are used to cause the tumor to express calreticulin and stimulate an immune response against the tumor and other tumors in a subject. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.Type: GrantFiled: May 27, 2014Date of Patent: August 11, 2015Assignee: NanoBlate Corp.Inventors: Richard Lee Nuccitelli, Pamela Nuccitelli, Joanne Lum, Kaying Lui, Brian Athos, Mark Kreis, Zachary Mallon, Jon Berridge
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Publication number: 20140358066Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are used to cause the tumor to express calreticulin and stimulate an immune response against the tumor and other tumors in a subject. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.Type: ApplicationFiled: May 27, 2014Publication date: December 4, 2014Applicant: NanoBlate Corp.Inventors: Richard Lee Nuccitelli, Pamela Nuccitelli, Joanne Lum, Kaying Lui, Brian Athos, Mark Kreis, Zachary Mallon, Jon Berridge
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Patent number: 8694088Abstract: The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.Type: GrantFiled: May 8, 2008Date of Patent: April 8, 2014Assignee: Bioelectromed Corp.Inventors: Richard Nuccitelli, Pamela Nuccitelli, Shr-Kai Liau, Uwe F. Pliquett, Changyi Li, Suman Narsing, Brian Athos, Saleh Sheikh
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Patent number: 8688227Abstract: A medical instrument for delivering electrotherapy is provided. The instrument includes an outer support member having an open distal end and a base wall portion within the support member arranged to form a cup-like volume at the distal end. The instrument also includes at least one aperture formed in the cup-like volume for applying a suction to the cup-like region. The instrument further includes a first and a second electrode having at least a portion within the cup region or proximate to the cup region for providing an electric field in the cup region when a bias signal is applied between the first and second electrodes.Type: GrantFiled: May 9, 2008Date of Patent: April 1, 2014Assignee: Old Dominion Research FoundationInventors: Richard L. Nuccitelli, Uwe F. Pliquett, Pamela Nuccitelli, Changyi Li, Saleh H. Sheikh
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Patent number: 8597187Abstract: The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.Type: GrantFiled: June 15, 2009Date of Patent: December 3, 2013Assignee: BioElectroMed Corp.Inventors: Richard Lee Nuccitelli, Pamela Nuccitelli, Suman Narsing, Brian Athos, Saleh Sheikh
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Patent number: 8512334Abstract: Nanosecond pulsed electric field (nsPEF) parameters for destroying tumors with a single treatment are described. A nsPEF generator may be used with an electrode assembly to apply the pulses to one or more tumors where the parameters for the nsPEF are optimized for treating such tumors.Type: GrantFiled: March 11, 2010Date of Patent: August 20, 2013Assignee: BioElectroMed CorporationInventors: Richard Lee Nuccitelli, Pamela Nuccitelli, Saleh Sheikh, Kevin Tran, Brian Athos, Mark Kreis
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Publication number: 20110009929Abstract: A medical instrument for delivering electrotherapy is provided. The instrument includes an outer support member having an open distal end and a base wall portion within the support member arranged to form a cup-like volume at the distal end. The instrument also includes at least one aperture formed in the cup-like volume for applying a suction to the cup-like region. The instrument further includes a first and a second electrode having at least a portion within the cup region or proximate to the cup region for providing an electric field in the cup region when a bias signal is applied between the first and second electrodes.Type: ApplicationFiled: May 9, 2008Publication date: January 13, 2011Inventors: Richard L. Nuccitelli, Uwe F. Pliquett, Pamela Nuccitelli, Changyi Li, Saleh H. Sheikh
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Publication number: 20100318082Abstract: Nanosecond pulsed electric field (nsPEF) parameters for destroying tumors with a single treatment are described. A nsPEF generator may be used with an electrode assembly to apply the pulses to one or more tumors where the parameters for the nsPEF are optimized for treating such tumors.Type: ApplicationFiled: March 11, 2010Publication date: December 16, 2010Applicant: BIOELECTROMED CORP.Inventors: Richard Lee NUCCITELLI, Pamela NUCCITELLI, Saleh SHEIKH, Kevin TRAN, Brian Athos, Mark KREIS
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Publication number: 20100240995Abstract: Systems and methods for treating tumors on or within internal organs of mammals that have been imaged with endoscopic ultrasound are described. The system uses an expandable bipolar electrode assembly that can be imaged by ultrasound and can penetrate, e.g., the stomach, intestine or bowel wall, etc. and be positioned in or around the tumor on an internal organ while being guided by an operator who visualizes its position with ultrasound imaging. It utilizes an electrode assembly that extends down an internal cavity in the endoscope to allow the operator to spread the electrodes for pulse delivery of a nanosecond pulsed electric field (nsPEF) to the tumor.Type: ApplicationFiled: March 17, 2010Publication date: September 23, 2010Applicant: BIOELECTROMED CORP.Inventors: Richard Lee NUCCITELLI, Pamela NUCCITELLI, Saleh SHEIKH, Kevin Tran, Brian Athos, Mark Kreis
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Publication number: 20100016686Abstract: The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.Type: ApplicationFiled: June 15, 2009Publication date: January 21, 2010Inventors: Richard Lee NUCCITELLI, Pamela NUCCITELLI, Suman NARSING, Brian ATHOS, Saleh SHEIKH