Patents by Inventor Pamela S. Keim

Pamela S. Keim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for inhibiting ?-secretase
    Patent number: 6852482
    Abstract: Compositions comprising a novel protease capable of cleaving ?-amyloid precursor protein (APP) on the amino-terminal side of the ?-amyloid peptide therein are provided. The protease is designated ?-secretase. Reaction systems comprising ?-secretase may be used in screening assays to monitor ?-secretase modulated cleavage of APP and to identify ?-secretase inhibitors, wherein the ?-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of ?-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: February 8, 2005
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Susanna M. S. Chrysler, Sukanto Sinha, Pamela S. Keim, John P. Anderson, Hua Tan, Lisa Clair McConlogue
  • &bgr;-secretase antibody
    Patent number: 6221645
    Abstract: Compositions comprising a novel protease capable of cleaving &bgr;-amyloid precursor protein (APP) on the amino-terminal side of the &bgr;-amyloid peptide therein are provided. The protease is designated &bgr;-secretase. Reaction systems comprising &bgr;-secretase may be used in screening assays to monitor &bgr;-secretase modulated cleavage of APP and to identify &bgr;-secretase inhibitors, wherein the &bgr;-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of &bgr;-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: April 24, 2001
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Susanna M. S. Chrysler, Sukanto Sinha, Pamela S. Keim, John P. Anderson, Hua Tan, Lisa Clair McConlogue
  • Integrin blocking molecule
    Patent number: 5811514
    Abstract: The invention relates to protein or polypeptide compositions capable of inhibiting leukocyte adhesion to, and transmigration across endothelial tissue. The invention further relates to nucleic acid molecules encoding such peptides, pharmaceutical compositions containing such peptides and methods of using such polypeptides.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 22, 1998
    Assignee: Athena Neurosciences
    Inventors: Frederique Bard, Theodore A. Yednock, Pamela S. Keim
  • .beta.-secretase
    Patent number: 5744346
    Abstract: Compositions comprising a novel protease capable of cleaving .beta.-amyloid precursor protein on the amino-terminal side of the .beta.-amyloid peptide therein are provided. The protease is designated .beta.-secretase. The .beta.-secretase may be used in screening assays to identify .beta.-secretase inhibitors, or the .beta.-secretase is combined with a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 28, 1998
    Assignee: Athena Neurosciences, Inc.
    Inventors: Susanna M. S. Chrysler, Sukanto Sinha, Pamela S. Keim, John P. Anderson