Patents by Inventor Pamela S. Nero

Pamela S. Nero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding oryza sativa nuclear cap binding protein 80 and methods of use
    Patent number: 7186887
    Abstract: An isolated polynucleotide encoding a full-length rice cap binding protein 80 (CBP80) is provided. The reduction in expression or activity of CBP80 in a transgenic rice plant cell may be accomplished by antisense sequences which can inhibit expression or activity of endogenous CBP80 in a rice plant cell which may lead to alterations in hormone signaling.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: March 6, 2007
    Assignee: Syngenta Participations AG
    Inventors: Joel Kreps, Pamela S. Nero
  • Antisense modulation of focal adhesion kinase expression
    Publication number: 20040192628
    Abstract: Compounds, compositions and methods are provided for inhibiting FAK mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding FAK. Methods of using these antisense compounds for inhibition of FAK expression and for treatment of diseases, particularly cancers, associated with overexpression or constitutive activation of FAK are provided.
    Type: Application
    Filed: August 22, 2003
    Publication date: September 30, 2004
    Inventors: Brett P. Monia, William A. Gaarde, Pamela S. Nero
  • Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
    Publication number: 20040029823
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.
    Type: Application
    Filed: January 15, 2003
    Publication date: February 12, 2004
    Inventors: Robert McKay, Nicholas M. Dean, Brett P. Monia, Pamela S. Nero, William A. Gaarde
  • Antisense modulation of focal adhesion kinase expression
    Publication number: 20010034329
    Abstract: Compounds, compositions and methods are provided for inhibiting FAK mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding FAK. Methods of using these antisense compounds for inhibition of FAK expression and for treatment of diseases, particularly cancers, associated with overexpression or constitutive activation of FAK are provided.
    Type: Application
    Filed: January 9, 2001
    Publication date: October 25, 2001
    Inventors: Brett P. Monia, William A. Gaarde, Pamela S. Nero
  • Antisense modulation of P38 mitogen activated protein kinase expression
    Patent number: 6140124
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: October 31, 2000
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Brett P. Monia, William A. Gaarde, Pamela S. Nero, Robert McKay
  • Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
    Patent number: 6133246
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: October 17, 2000
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Robert McKay, Nicholas Dean, Brett P. Monia, Pamela S. Nero, William A. Gaarde