Patents by Inventor Pamela S. Ohashi

Pamela S. Ohashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-cancer T cells and their preparation using coenzyme A
    Patent number: 11547725
    Abstract: There is described herein, a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population; and c) culturing or contacting the population of CD8+ T cells with Coenzyme A.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: January 10, 2023
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Pamela S. Ohashi, Michael St. Paul, Sam Saibil
  • Anti-tumor T cells and their preparation using IL-6
    Patent number: 11191782
    Abstract: There is described herein a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population of CD8+ T cells; and c) culturing or contacting the population of CD8+ T cells with IL-6.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Pamela S. Ohashi, Michael St. Paul
  • REGULATION OF TUMOR-ASSOCIATED T CELLS
    Publication number: 20210290672
    Abstract: There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56+CD3? innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.
    Type: Application
    Filed: August 17, 2017
    Publication date: September 23, 2021
    Inventors: Thuy-Linh NGUYEN, Pamela S. OHASHI, Sarah CROME
  • Methods and compositions for modulating toso activity
    Patent number: 10822388
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • ANTI-TUMOR T CELLS AND THEIR PREPARATION USING IL-6
    Publication number: 20200138862
    Abstract: There is described herein a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population of CD8+ T cells; and c) culturing or contacting the population of CD8+ T cells with IL-6.
    Type: Application
    Filed: December 19, 2017
    Publication date: May 7, 2020
    Inventors: Pamela S. OHASHI, Michael ST. PAUL
  • ANTI-CANCER T CELLS AND THEIR PREPARATION USING COENZYME A
    Publication number: 20190365813
    Abstract: There is described herein, a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population; and c) culturing or contacting the population of CD8+ T cells with Coenzyme A.
    Type: Application
    Filed: December 21, 2017
    Publication date: December 5, 2019
    Inventors: Pamela S. OHASHI, Michael ST. PAUL, Sam SAIBIL
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20180016320
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: May 1, 2017
    Publication date: January 18, 2018
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating toso activity
    Patent number: 9670265
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 6, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9624289
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 18, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9321824
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 26, 2016
    Assignee: Universal Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9228006
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 5, 2016
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150299292
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 22, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150197551
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: July 16, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150139995
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20130281356
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin