Patents by Inventor Pamela Small

Pamela Small has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mycolactone locus: an assembly line for producing novel polyketides, therapeutic and prophylactic uses
    Publication number: 20060024806
    Abstract: The present invention relates to Mycobacterium ulcerans virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and sufficient for mycolactone biosynthesis. More particularly this invention is directed to novel purified or isolated polypeptides, the polynucleotides encoding such polypeptides, processes for production of such polypeptides, antibodies generated against these polypeptides, the use of such polynucleotides and polypeptides in Diagnostic methods, kits, vaccines, therapy and for the production of mycolactone derivatives or novel polyketides by combinatorial synthesis.
    Type: Application
    Filed: July 7, 2005
    Publication date: February 2, 2006
    Inventors: Timothy Stinear, Stewart Cole, Peter Leadlay, Pamela Small, Paul Johnson, Grant Jenkin, John Davies, Stephen Haydock