Patents by Inventor Pamela T. Manning

Pamela T. Manning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the treatment of respiratory diseases and conditions using a selective iNOS inhibitor
    Publication number: 20040077639
    Abstract: Therapeutic methods for the prevention and treatment of respiratory diseases or conditions are described, the methods including administering to a subject in need thereof a respiratory disease or condition effective amount of a selective inhibitor of inducible nitric oxide synthase.
    Type: Application
    Filed: May 16, 2003
    Publication date: April 22, 2004
    Inventor: Pamela T. Manning
  • Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors
    Patent number: 6653350
    Abstract: Methods of treating osteoarthritis by administering an therapeutically effective amount of NOS inhibitor are provided.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: November 25, 2003
    Assignees: G.D. Searle & Co., Pharmacia Corporation
    Inventors: Pamela T. Manning, Jane R. Connor, Mark G. Currie, Jean Pierre Pelletier, Johanne Martel Pelletier
  • Methods of making amidino compounds useful as nitric oxide synthase inhibitors
    Publication number: 20030199701
    Abstract: A method of making an alpha-amino acid compound having the structure of Formula 32: 1
    Type: Application
    Filed: December 17, 2002
    Publication date: October 23, 2003
    Applicant: Pharmacia Corporate
    Inventors: Ronald Keith Webber, Richard C. Durley, Alok K. Awasthi, Arija A. Bergmanis, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • Amidino compounds useful as nitric oxide synthase inhibitors
    Patent number: 6586474
    Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: July 1, 2003
    Assignee: Pharmacia Corporation
    Inventors: Ronald Keith Webber, Richard C. Durley, Alok K. Awasthi, Arija A. Bergmanis, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6586471
    Abstract: The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: July 1, 2003
    Assignee: G. D. Searle
    Inventors: Donald W. Hansen, Jr., Barnett S. Pitzele, Ronald Keith Webber, Mihaly V. Toth, Pamela T. Manning, Alok K. Awasthi, Mahima Trivedi
  • Neuroprotective treatment methods using selective iNOS inhibitors
    Publication number: 20030119826
    Abstract: Therapeutic methods for the prevention and treatment of neurodegenerative conditions are described, the methods including administering to a subject in need thereof a neuroprotective effective amount of a selective inhibitor of inducible nitric oxide synthase.
    Type: Application
    Filed: September 24, 2001
    Publication date: June 26, 2003
    Applicant: Pharmacia Corporation
    Inventors: Pamela T. Manning, Jane R. Connor
  • Ophthalmologic treatment methods using selective iNOS inhibitors
    Publication number: 20030109522
    Abstract: Therapeutic methods for the prevention and treatment of ophthalmologic conditions are described, the methods including administering to a subject in need thereof a selective inhibitor of inducible nitric oxide synthase.
    Type: Application
    Filed: September 24, 2001
    Publication date: June 12, 2003
    Inventors: Pamela T. Manning, Jane R. Connor
  • Agents and methods for treatment of cancer
    Publication number: 20030013702
    Abstract: Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxygenase-2 in a pharmaceutical composition. The agents and methods are used for chemoprevention and treatment of neoplasia including colorectal cancer and other cancers affecting epithelial cells throughout the body. The agents can also be used to treat the fibrosis that occurs with radiation therapy, as well as adenomatous polyps, including those with familial adenomatous polyposis (FAP).
    Type: Application
    Filed: September 24, 2001
    Publication date: January 16, 2003
    Inventors: Pamela T. Manning, Jane R. Connor, Karen Seibert, Chinthalapally V. Rao, Bandaru S. Reddy
  • Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6465518
    Abstract: The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: October 15, 2002
    Assignee: Pharmacia Corporation
    Inventors: Donald W. Hansen, Jr., Ronald Keith Webber, Alok K. Awasthi, Pamela T. Manning
  • Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6465686
    Abstract: The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: October 15, 2002
    Assignee: Pharmacia Corporation
    Inventors: Margaret L. Grapperhaus, James A. Sikorski, Alok K. Awasthi, Lijuan J. Wang, Barnett S. Pitzele, Donald W. Hansen, Jr., Pamela T. Manning
  • Amidino compounds useful as nitric oxide synthase inhibitors
    Publication number: 20020111493
    Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
    Type: Application
    Filed: March 23, 2001
    Publication date: August 15, 2002
    Inventors: Ronald Keith Webber, Alok K. Awasthi, Arija A. Bergmanis, Richard C. Durley, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020049202
    Abstract: The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Application
    Filed: April 13, 2001
    Publication date: April 25, 2002
    Inventors: Margaret L. Grapperhaus, James A. Sikorski, Alok K. Awasthi, Lijuan J. Wang, Barnett S. Pitzele, Donald W. Hansen, Pamela T. Manning
  • Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020037927
    Abstract: The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Application
    Filed: April 13, 2001
    Publication date: March 28, 2002
    Inventors: Donald W. Hansen, Ronald Keith Webber, Alok K. Awasthi, Pamela T. Manning