Patents by Inventor Pamela Tan

Pamela Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
    Publication number: 20250171785
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
    Type: Application
    Filed: November 1, 2024
    Publication date: May 29, 2025
    Inventors: Pamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
  • Apparatus and method for protecting an operating field
    Patent number: 12201394
    Abstract: An apparatus for protecting an operating field. The apparatus includes a sheet configured to cover a patient's hair during an operation. A sealing member is provided on or joined to a leading end of the sheet. The sealing member is configured to be applied to a patient's skin adjacent to an operating field to create a seal between the operating field and the patient's hair. At least one anchoring member is joined to the sheet adjacent to the leading end of the sheet. The at least one anchoring member is configured to be attached to the patient's hair adjacent to the operating field to anchor the apparatus to the patient.
    Type: Grant
    Filed: April 17, 2023
    Date of Patent: January 21, 2025
    Assignee: MEDSTAR HEALTH, INC.
    Inventors: Alexandra Tilt, Pamela Tan
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE
    Publication number: 20240401060
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.
    Type: Application
    Filed: November 29, 2023
    Publication date: December 5, 2024
    Applicants: ALNYLAM PHARMACEUTICALS, INC., LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
    Inventors: DINAH SAH, PAMELA TAN, WEBSTER CAVENEE, FRANK FURNARI, MARIA DEL MAR INDA PEREZ, RUDY BONAVIA
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
    Publication number: 20240093199
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
    Type: Application
    Filed: March 3, 2023
    Publication date: March 21, 2024
    Inventors: Pamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
  • APPARATUS AND METHOD FOR PROTECTING AN OPERATING FIELD
    Publication number: 20230248458
    Abstract: An apparatus for protecting an operating field. The apparatus includes a sheet configured to cover a patient’s hair during an operation. A sealing member is provided on or joined to a leading end of the sheet. The sealing member is configured to be applied to a patient’s skin adjacent to an operating field to create a seal between the operating field and the patient’s hair. At least one anchoring member is joined to the sheet adjacent to the leading end of the sheet. The at least one anchoring member is configured to be attached to the patient’s hair adjacent to the operating field to anchor the apparatus to the patient.
    Type: Application
    Filed: April 17, 2023
    Publication date: August 10, 2023
    Inventors: Alexandra TILT, Pamela Tan
  • Apparatus and method for helping to protect a patient#s hair
    Patent number: 11648077
    Abstract: An apparatus for helping to protect a patient's hair is provided. The apparatus includes a sheet configured to cover a patient's hair during an operation. A sealing member is provided on or joined to a leading end of the sheet. The sealing member is configured to be applied to a patient's skin adjacent to an operating field to create a seal between the operating field and the patient's hair. At least one anchoring member is joined to the sheet adjacent to the leading end of the sheet. The at least one anchoring member is configured to be attached to the patient's hair adjacent to the operating field to anchor the apparatus to the patient.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: May 16, 2023
    Assignee: MEDSTAR HEALTH, INC.
    Inventors: Alexandra Tilt, Pamela Tan
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE
    Publication number: 20230053332
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.
    Type: Application
    Filed: April 29, 2022
    Publication date: February 23, 2023
    Applicants: ALNYLAM PHARMACEUTICALS, INC., LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
    Inventors: DINAH SAH, PAMELA TAN, WEBSTER CAVENEE, FRANK FURNARI, MARIA DEL MAR INDA PEREZ, RUDY BONAVIA
  • RNAi Inhibition of Alpha-ENaC Expression
    Publication number: 20220235361
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Application
    Filed: April 5, 2022
    Publication date: July 28, 2022
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, Hans-Peter Vornlocher
  • RNAi Inhibition of Alpha-ENaC Expression
    Publication number: 20220112505
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 14, 2022
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, Hans-Peter Vornlocher
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
    Publication number: 20210403917
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
    Type: Application
    Filed: February 26, 2021
    Publication date: December 30, 2021
    Applicant: Alnylam Pharmaceuticals, Inc.
    Inventors: Pamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
  • RNAi inhibition of alpha-ENaC expression
    Patent number: 11208662
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 28, 2021
    Assignee: Arrowhead Pharmaceuticals, Inc.
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, Hans-Peter Vornlocher
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE
    Publication number: 20200377893
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.
    Type: Application
    Filed: March 3, 2020
    Publication date: December 3, 2020
    Inventors: Dinah Sah, Pamela Tan, Webster Cavenee, Frank Furnari, Maria del Mar Inda Perez, Rudy Bonavia
  • APPARATUS AND METHOD FOR HELPING TO PROTECT A PATIENT'S HAIR
    Publication number: 20200375683
    Abstract: An apparatus for helping to protect a patient's hair is provided. The apparatus includes a sheet configured to cover a patient's hair during an operation. A sealing member is provided on or joined to a leading end of the sheet. The sealing member is configured to be applied to a patient's skin adjacent to an operating field to create a seal between the operating field and the patient's hair. At least one anchoring member is joined to the sheet adjacent to the leading end of the sheet. The at least one anchoring member is configured to be attached to the patient's hair adjacent to the operating field to anchor the apparatus to the patient.
    Type: Application
    Filed: May 27, 2020
    Publication date: December 3, 2020
    Inventors: Alexandra Tilt, Pamela Tan
  • Compositions and Methods for Inhibiting Expression of the PCSK9 Gene
    Publication number: 20200318119
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
    Type: Application
    Filed: November 5, 2019
    Publication date: October 8, 2020
    Inventors: Pamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
  • RNAi Inhibition of Alpha-ENaC Expression
    Publication number: 20200157550
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, JR., Hans-Peter Vornlocher
  • RNAi inhibition of alpha-ENaC expression
    Patent number: 10544418
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 28, 2020
    Assignee: Arrowhead Pharmaceuticals, Inc.
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, Hans-Peter Vornlocher
  • Compositions and methods for inhibiting expression of the PCSK9 gene
    Patent number: 10501742
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: December 10, 2019
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Pamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE
    Publication number: 20190010502
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.
    Type: Application
    Filed: March 30, 2018
    Publication date: January 10, 2019
    Inventors: Dinah Sah, Pamela Tan, Webster Cavenee, Frank Furnari, Maria del Mar Inda Perez, Rudy Bonavia
  • Compositions and Methods for Inhibiting Expression of the PCSK9 Gene
    Publication number: 20180216115
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
    Type: Application
    Filed: November 8, 2017
    Publication date: August 2, 2018
    Inventors: Pamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
  • RNAi Inhibition of Alpha-ENaC Expression
    Publication number: 20180148726
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Application
    Filed: January 18, 2018
    Publication date: May 31, 2018
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, Hans-Peter Vornlocher