Patents by Inventor Pamela Tiet

Pamela Tiet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid-functionalized nanoparticles
    Patent number: 11549941
    Abstract: Provided herein are functionalized nanoparticle compositions and methods of using the same. The functionalized nanoparticles provided include a nuclease cleavage site and are, inter alia, useful for the formation of nanoparticle aggregates and detection of nuclease activity through nanoparticle aggregate formation.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: January 10, 2023
    Assignee: CITY OF HOPE
    Inventors: Jacob Berlin, Pamela Tiet
  • Silica nanoparticle with an insoluble drug
    Patent number: 11191745
    Abstract: Disclosed herein, inter alia, are nanoparticle compositions (e.g., silica nanoparticles) including insoluble drug nanocrystals and methods of using the same for treating cancer.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: December 7, 2021
    Assignee: CITY OF HOPE
    Inventors: Pamela Tiet, Jacob Berlin
  • PRE-CONDITIONED EXTRACELLULAR VESICLES AND METHODS OF PRODUCTION
    Publication number: 20210052641
    Abstract: A method for treating inflammatory diseases is provided. The method may include administering to a subject in need thereof a therapeutically effective amount of isolated extracellular vesicles or exosomes obtained from mesenchymal stem cells pre-conditioned with at least TNF-?. The isolated extracellular vesicles or exosomes may exhibit (a) enhanced expression of flotillin-1, (b) enhanced expression of CD73, or (c) enhanced expression of IDO. A method of isolating extracellular vesicles or exosomes capable of treating an inflammatory disease is also provided, wherein the method may include (a) culturing stem cells in a growth medium, (b) then culturing the stem cells in a starve medium supplemented with at least TNF-?, and (c) separating exosomes or extracellular vesicles from the culture. Cultures suitable for treatment are also provided.
    Type: Application
    Filed: August 21, 2020
    Publication date: February 25, 2021
    Applicant: United Therapeutics Corporation
    Inventors: Pamela Tiet, Roger Ilagan
  • SILICA NANOPARTICLE WITH AN INSOLUBLE DRUG
    Publication number: 20200316010
    Abstract: Disclosed herein, inter alia, are nanoparticle compositions (e.g., silica nanoparticles) including insoluble drug nanocrystals and methods of using the same for treating cancer.
    Type: Application
    Filed: February 2, 2018
    Publication date: October 8, 2020
    Inventors: Pamela TIET, Jacob BERLIN
  • NUCLEIC ACID-FUNCTIONALIZED NANOPARTICLES
    Publication number: 20200191781
    Abstract: Provided herein are functionalized nanoparticle compositions and methods of using the same. The functionalized nanoparticles provided include a nuclease cleavage site and are, inter alia, useful for the formation of nanoparticle aggregates and detection of nuclease activity through nanoparticle aggregate formation.
    Type: Application
    Filed: February 12, 2020
    Publication date: June 18, 2020
    Inventors: Jacob Berlin, Pamela Tiet
  • NUCLEIC ACID-FUNCTIONALIZED NANOPARTICLES
    Publication number: 20170122938
    Abstract: Provided herein are functionalized nanoparticle compositions and methods of using the same. The functionalized nanoparticles provided include a nuclease cleavage site and are, inter alia, useful for the formation of nanoparticle aggregates and detection of nuclease activity through nanoparticle aggregate formation.
    Type: Application
    Filed: October 31, 2016
    Publication date: May 4, 2017
    Inventors: Jacob Berlin, Pamela Tiet