Abstract: A pillow for coupling to a surface. The pillow includes: a first cushion of soft resilient material; a first cover enclosing the cushion; a second cover enclosing the first cover, the second cover including an edge portion having a first aperture disposed therethrough; and a suction cup assembly coupled to the first cover and disposed through the first aperture. The suction cup assembly includes: a suction cup; a release tab coupled to an edge of the suction cup; a neck; a nub coupled to the neck and having a larger dimension than a radius of the neck; a second cushion of soft resilient material disposed about the neck and between the first cover and the nub; and a rigid annular member disposed about the neck and between the second cushion and the nub, wherein the second cushion extends radially beyond the rigid annular member.

Abstract: A pillow for coupling to a surface. The pillow includes: a first cushion; a first cover enclosing the first cushion; a second cover enclosing the first cover, the second cover including: a first end, having a first corner; a second end, disposed opposite the first end, having a second corner; and a first aperture disposed near the first corner; wherein the first aperture is large enough to permit ingress and egress of the first cushion therethrough; and an elongated band member, coupled to the first end and the second end, respectively, thereby forming an opening between the elongated band member and the second cover. The pillow further includes: a loop member, coupled to the second end; a carrying strap member coupled to the first corner and the second corner, respectively; a pair of D-rings, each D-ring coupled to the first corner and the second corner, respectively; and a slide fastener.

Abstract: Systems and methods are provided for analyzing a set of assets. Generally, a distribution is computed for a characteristic of assets, setting a range in a tail of the distribution and partitioning the range into at least one partition. Subsequently, a multiplier is assigned to each partition, wherein the multiplier represents how the characteristics affect the risk associated with an asset. These multipliers can be used in a risk analysis.

Abstract: A pillow for coupling to a surface. The pillow includes: a first cushion; a first cover enclosing the first cushion; a second cover enclosing the first cover, the second cover including: a first end, having a first corner; a second end, disposed opposite the first end, having a second corner; and a first aperture disposed near the first corner; wherein the first aperture is large enough to permit ingress and egress of the first cushion therethrough; and an elongated band member, coupled to the first end and the second end, respectively, thereby forming an opening between the elongated band member and the second cover. The pillow further includes: a loop member, coupled to the second end; a carrying strap member coupled to the first corner and the second corner, respectively; a pair of D-rings, each D-ring coupled to the first corner and the second corner, respectively; and a slide fastener.

Abstract: A pillow for coupling to a surface. The pillow includes: a first cushion of soft resilient material; a first cover enclosing the cushion; a second cover enclosing the first cover, the second cover including an edge portion having a first aperture disposed therethrough; and a suction cup assembly coupled to the first cover and disposed through the first aperture. The suction cup assembly includes: a suction cup; a release tab coupled to an edge of the suction cup; a neck; a nub coupled to the neck and having a larger dimension than a radius of the neck; a second cushion of soft resilient material disposed about the neck and between the first cover and the nub; and a rigid annular member disposed about the neck and between the second cushion and the nub, wherein the second cushion extends radially beyond the rigid annular member.

Abstract: The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structure of related cytochrome P450 molecules.

Abstract: The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from said culture and suspending said cells in a high salt buffer; lysing said cells and removing cell debris to provide a high-salt lysate; adding to said lysate a detergent to provide a high-salt-detergent lysate; and recovering said P450 from said lysate. The method provides yields of P450 proteins suitable for crystallization.

Abstract: The present invention provides co-crystals of cytochrome P450 2C9 proteins and a ligand such as warfarin which has been crystallised to provide a high resolution structure. The structure may be used for homology modelling of other cytochrome P450 structures such as 2C8, 2C18 and 2C19, and for analysis of the interaction of ligands with P450.

Abstract: The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from said culture and suspending said cells in a high salt buffer; lysing said cells and removing cell debris to provide a high-salt lysate; adding to said lysate a detergent to provide a high-salt-detergent lysate; and recovering said P450 from said lysate. The method provides yields of P450 proteins suitable for crystallization.

Abstract: The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structure of related cytochrome P450 molecules.

Abstract: The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structure of related cytochrome P450 molecules.