Abstract: Provided are a display substrate, a preparation method thereof, and a display device. The display substrate includes a display region and a bonding region on one side of the display region. The bonding region at least includes a lead area; the display region includes a plurality of data lines and a plurality of data fanout lines, the lead area includes a plurality of lead wires, and orthographic projections of the plurality of data lines and the plurality of data fanout lines on a plane of the display substrate are at least partially overlapped. At least one lead wire is connected to the data line through the data fanout line. In the lead area, an orthographic projection of any one of the lead wires on the plane of the display substrate and orthographic projections of other lead wires on the plane of the display substrate have no overlap region.

Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.

Abstract: The cleaning device includes a water injection member and a mopping cloth cleaning member. The water injection member is configured to wet the mopping cloth of a cleaning robot. The mopping cloth cleaning member which reciprocates up and down to flap the mopping cloth of the cleaning robot, in order to clean the mopping cloth of the cleaning robot.

Abstract: Disclosed is an underbalanced drilling vibrating screen integrated with automatic drainage and vacuum chucks, and belongs to the technical field of solid-phase control of petroleum drilling. The underbalanced drilling vibrating screen comprises a base, a screening device and a negative pressure generating device, wherein the screening device and the negative pressure generating device are arranged on the base; the screening device comprises a shell, an exciting motor arranged on the shell, a plurality of screens arranged in the shell, and at least one drainage component; and the drainage component communicates with at least one screen through the vacuum chuck, the negative pressure generating device communicates with the vacuum chuck, and the drainage component is integrally formed with the vacuum chuck.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: Provided herein are methods and systems for multi-analyte detection of cancer. The methods may comprise assaying multiple nucleic acids to detect a set of biomarkers from samples. The methods may comprise processing the set of biomarkers to determine the presence of a cancer or cancer parameters. The processing may be performed by an algorithm. The algorithm may be a trained algorithm and may be trained on multiple training samples.

Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.

Abstract: Provided herein are methods and systems monitoring of cancer using minimal residual disease analysis. The methods may comprise assaying multiple nucleic acids to detect a set of biomarkers from samples. The methods may comprise sequencing of nucleic acids. The method may comprise the generation of a probe panel. The methods may comprise processing the set of biomarkers to determine the presence of a cancer or cancer parameters. The processing may be performed by an algorithm.

Abstract: Provided herein are devices and methods for collection of a biological sample. The device may comprise a cap, a pierceable container comprising a reagent for processing or preserving a biological sample, and a container that comprises a piercer. Upon engagement of the cap with an opening of the container, the piercer may be able to pierce a pierceable container, thereby releasing the reagent of the pierceable container into the container. The methods may comprise use of the device to collect a biological sample. The methods may comprise assaying analytes of the biological sample.

Abstract: Disclosed are systems and methods for detecting genetic alterations comprising androgen receptor gene splice variants (AR-Vs), mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection of gene alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof of other genes of interest. The streamlined methods improve the consistency and simplicity of non-invasive detections of biomarkers.

Abstract: An in-situ test device and method for surrounding rock strength of bolt supported roadway is provided. The test device includes a fixing mechanism, a loading mechanism, a measuring mechanism and a control system. The loading mechanism includes a hydraulic pump and a plunger pump, the hydraulic pump drives the plunger pump to work and controls the lifting speed of the loading cylinder; the measuring mechanism includes an infrared ranging unit and a wireless pressure monitoring unit; the control system controls the work of the loading mechanism and processes the monitoring data. The test device is directly installed in the roadway and fixed with the bolt. The device is loaded after leveling, the device is disassembled after the monitoring data are obtained, and the in-situ test for the surrounding rock strength of the bolt supported roadway is completed. The steps are simple and adaptable.

Abstract: Disclosed are systems and methods for detecting genetic alterations comprising androgen receptor gene splice variants (AR-Vs), mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection of gene alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof of other genes of interest. The streamlined methods improve the consistency and simplicity of non-invasive detections of biomarkers.

Abstract: An in-situ test device and method for surrounding rock strength of bolt supported roadway is provided. The test device includes a fixing mechanism, a loading mechanism, a measuring mechanism and a control system. The loading mechanism includes a hydraulic pump and a plunger pump, the hydraulic pump drives the plunger pump to work and controls the lifting speed of the loading cylinder; the measuring mechanism includes an infrared ranging unit and a wireless pressure monitoring unit; the control system controls the work of the loading mechanism and processes the monitoring data. The test device is directly installed in the roadway and fixed with the bolt. The device is loaded after leveling, the device is disassembled after the monitoring data are obtained, and the in-situ test for the surrounding rock strength of the bolt supported roadway is completed. The steps are simple and adaptable.

Abstract: The cleaning device includes a water injection member and a mopping cloth cleaning member. The water injection member is configured to wet the mopping cloth of a cleaning robot. The mopping cloth cleaning member which reciprocates up and down to flap the mopping cloth of the cleaning robot, in order to clean the mopping cloth of the cleaning robot.

Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.

Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.

Abstract: Disclosed are systems and methods for diagnosing a disease status or progression of a disease comprising detection and correlation of methylation and expression level changes of cancer markers including PD-L1 in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection and correlation of methylation and expression level changes in solid tissues. The present method utilized a barcoding method for analysis. The systems and methods can be used for predicting immunotherapy resistant cancer and monitoring therapy response.

Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.

Abstract: Disclosed are systems and methods for detecting genetic alterations comprising androgen receptor gene splice variants (AR-Vs), mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection of gene alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof of other genes of interest. The streamlined methods improve the consistency and simplicity of non-invasive detections of biomarkers.