Patents by Inventor Pan DU

Pan DU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250067179
    Abstract: The present disclosure provides a monitoring and warning device for rock burst in coal mine, which is configured for monitoring a rock mass in a drill hole, the monitoring and warning device for rock burst in coal mine includes: an integration rod, radial adjustment components, a plurality of bases, and a measuring instrument, the integration rod is extended into the drill hole; the radial adjustment components are provided on the integration rod, and have a plurality of radial adjustment ends; a plurality of bases are correspondingly provided in the radial adjustment ends, and the bases are further connected with attachment components through elastic components, and the attachment components are embedded with first strain gauges; the measuring instrument is rotatably provided in the integration rod, and is used to measure the distance between the measuring instrument and the attachment components.
    Type: Application
    Filed: August 6, 2024
    Publication date: February 27, 2025
    Inventors: Hongtu ZHANG, Mian WANG, Zhibo ZHANG, Chao GUO, Xiangyang WANG, Fenggang ZHANG, Dong CHEN, Pan CHEN, Duzhou LI, Liuqun DU, Lianbo HUANG, Jinhua LI, Junfang LI, He SUN, Zhen LI, Gongda WANG, Xu CHEN, Weiyong LU
  • Patent number: 12234732
    Abstract: The present disclosure provides a monitoring and warning device for rock burst in coal mine, which is configured for monitoring a rock mass in a drill hole, the monitoring and warning device for rock burst in coal mine includes: an integration rod, radial adjustment components, a plurality of bases, and a measuring instrument, the integration rod is extended into the drill hole; the radial adjustment components are provided on the integration rod, and have a plurality of radial adjustment ends; a plurality of bases are correspondingly provided in the radial adjustment ends, and the bases are further connected with attachment components through elastic components, and the attachment components are embedded with first strain gauges; the measuring instrument is rotatably provided in the integration rod, and is used to measure the distance between the measuring instrument and the attachment components.
    Type: Grant
    Filed: August 6, 2024
    Date of Patent: February 25, 2025
    Assignee: Henan Polytechnic University
    Inventors: Hongtu Zhang, Mian Wang, Zhibo Zhang, Chao Guo, Xiangyang Wang, Fenggang Zhang, Dong Chen, Pan Chen, Duzhou Li, Liuqun Du, Lianbo Huang, Jinhua Li, Junfang Li, He Sun, Zhen Li, Gongda Wang, Xu Chen, Weiyong Lu
  • Patent number: 12227557
    Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: February 18, 2025
    Assignees: OncoC4, Inc., Children's National Medical Center
    Inventors: Yang Liu, Pan Zheng, Martin Devenport, Wei Wu, Xuexiang Du, Mingyue Liu, Fei Tang
  • Patent number: 12222331
    Abstract: Provided are a system and a method for impact testing and monitoring of a high-energy flexible net. The system includes a vertical impact testing unit, a slope impact testing unit, an impact simulation unit, and an impact monitoring unit. The vertical impact testing unit includes a vertically positioned gravity wall. The slope impact testing unit includes a wall slope positioned perpendicularly to a second side of the gravity wall. A first side of the gravity wall and a slope surface of the wall slope are securely provided with a flexible net, respectively. The impact simulation unit includes an impact assembly and a lifting assembly. The impact monitoring unit is configured to monitor a deformation result and an internal force change result of the flexible net.
    Type: Grant
    Filed: September 26, 2024
    Date of Patent: February 11, 2025
    Assignees: RAILWAY ENGINEERING RESEARCH INSTITUTE, CHINA ACADEMY OF RAILWAY SCIENCES CO., LTD., CHINA ACADEMY OF RAILWAY SCIENCES CO., LTD.
    Inventors: Yufang Zhang, Kun Yuan, Xiaobing Li, Yong Yao, Tao Jia, Lining Du, Tao Wei, Wenchao Zhang, Jian Cui, Bo Liu, Jian Li, Yu Cheng, Shengyong Zeng, Shuangquan Lei, Shiwen Huang, Wenxin Tan, Junjie Zeng, Hao Lan, Jiawei Fan, Ning Xuan, Peng Zhang, Gongming Chen, Pan Chen, Fei Xian, Zehua Dong
  • Publication number: 20250043003
    Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.
    Type: Application
    Filed: September 24, 2024
    Publication date: February 6, 2025
    Inventors: Yang Liu, Pan Zheng, Fei Tang, Mingyue Liu, Martin Devenport, Xuexiang Du, Yan Zhang
  • Publication number: 20240417777
    Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.
    Type: Application
    Filed: January 8, 2024
    Publication date: December 19, 2024
    Inventors: Xiaohong WANG, Pan DU, Shidong JIA
  • Patent number: 12150611
    Abstract: The cleaning device includes a water injection member and a mopping cloth cleaning member. The water injection member is configured to wet the mopping cloth of a cleaning robot. The mopping cloth cleaning member which reciprocates up and down to flap the mopping cloth of the cleaning robot, in order to clean the mopping cloth of the cleaning robot.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: November 26, 2024
    Assignee: SHENZHEN FLY RODENT DYNAMICS INTELLIGENT TECHNOLOGY CO., LTD.
    Inventors: Pan Du, Linlin Zhou
  • Publication number: 20240279745
    Abstract: Provided herein are methods and systems for multi-analyte detection of cancer. The methods may comprise assaying multiple nucleic acids to detect a set of biomarkers from samples. The methods may comprise processing the set of biomarkers to determine the presence of a cancer or cancer parameters. The processing may be performed by an algorithm. The algorithm may be a trained algorithm and may be trained on multiple training samples.
    Type: Application
    Filed: September 28, 2023
    Publication date: August 22, 2024
    Inventors: Pan DU, Binggang XIANG, Chao DAI, Shujun LUO, Shidong JIA
  • Patent number: 11913063
    Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: February 27, 2024
    Assignee: PREDICINE, INC.
    Inventors: Xiaohong Wang, Pan Du, Shidong Jia
  • Publication number: 20230415145
    Abstract: Provided herein are devices and methods for collection of a biological sample. The device may comprise a cap, a pierceable container comprising a reagent for processing or preserving a biological sample, and a container that comprises a piercer. Upon engagement of the cap with an opening of the container, the piercer may be able to pierce a pierceable container, thereby releasing the reagent of the pierceable container into the container. The methods may comprise use of the device to collect a biological sample. The methods may comprise assaying analytes of the biological sample.
    Type: Application
    Filed: June 23, 2023
    Publication date: December 28, 2023
    Inventors: Shujun LUO, Pan DU, Shidong JIA
  • Publication number: 20230416833
    Abstract: Provided herein are methods and systems monitoring of cancer using minimal residual disease analysis. The methods may comprise assaying multiple nucleic acids to detect a set of biomarkers from samples. The methods may comprise sequencing of nucleic acids. The method may comprise the generation of a probe panel. The methods may comprise processing the set of biomarkers to determine the presence of a cancer or cancer parameters. The processing may be performed by an algorithm.
    Type: Application
    Filed: February 2, 2023
    Publication date: December 28, 2023
    Inventors: Shidong JIA, Pan DU
  • Publication number: 20230304103
    Abstract: Disclosed are systems and methods for detecting genetic alterations comprising androgen receptor gene splice variants (AR-Vs), mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection of gene alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof of other genes of interest. The streamlined methods improve the consistency and simplicity of non-invasive detections of biomarkers.
    Type: Application
    Filed: May 26, 2023
    Publication date: September 28, 2023
    Inventors: Shidong JIA, Pan DU, Xiaohong WANG
  • Patent number: 11702702
    Abstract: Disclosed are systems and methods for detecting genetic alterations comprising androgen receptor gene splice variants (AR-Vs), mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection of gene alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof of other genes of interest. The streamlined methods improve the consistency and simplicity of non-invasive detections of biomarkers.
    Type: Grant
    Filed: April 16, 2017
    Date of Patent: July 18, 2023
    Assignee: Predicine, Inc.
    Inventors: Shidong Jia, Pan Du, Xiaohong Wang
  • Patent number: 11703432
    Abstract: An in-situ test device and method for surrounding rock strength of bolt supported roadway is provided. The test device includes a fixing mechanism, a loading mechanism, a measuring mechanism and a control system. The loading mechanism includes a hydraulic pump and a plunger pump, the hydraulic pump drives the plunger pump to work and controls the lifting speed of the loading cylinder; the measuring mechanism includes an infrared ranging unit and a wireless pressure monitoring unit; the control system controls the work of the loading mechanism and processes the monitoring data. The test device is directly installed in the roadway and fixed with the bolt. The device is loaded after leveling, the device is disassembled after the monitoring data are obtained, and the in-situ test for the surrounding rock strength of the bolt supported roadway is completed. The steps are simple and adaptable.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: July 18, 2023
    Assignee: SHANDONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Fenghai Yu, Xuerui Yang, Yunliang Tan, Qiang Ren, Kai Zhou, Chuang Zhang, Pan Du, Qingduo Wang
  • Publication number: 20220364967
    Abstract: An in-situ test device and method for surrounding rock strength of bolt supported roadway is provided. The test device includes a fixing mechanism, a loading mechanism, a measuring mechanism and a control system. The loading mechanism includes a hydraulic pump and a plunger pump, the hydraulic pump drives the plunger pump to work and controls the lifting speed of the loading cylinder; the measuring mechanism includes an infrared ranging unit and a wireless pressure monitoring unit; the control system controls the work of the loading mechanism and processes the monitoring data. The test device is directly installed in the roadway and fixed with the bolt. The device is loaded after leveling, the device is disassembled after the monitoring data are obtained, and the in-situ test for the surrounding rock strength of the bolt supported roadway is completed. The steps are simple and adaptable.
    Type: Application
    Filed: July 25, 2022
    Publication date: November 17, 2022
    Inventors: Fenghai YU, Xuerui YANG, Yunliang TAN, Qiang REN, Kai ZHOU, Chuang ZHANG, Pan DU, Qingduo WANG
  • Publication number: 20220304543
    Abstract: The cleaning device includes a water injection member and a mopping cloth cleaning member. The water injection member is configured to wet the mopping cloth of a cleaning robot. The mopping cloth cleaning member which reciprocates up and down to flap the mopping cloth of the cleaning robot, in order to clean the mopping cloth of the cleaning robot.
    Type: Application
    Filed: December 9, 2021
    Publication date: September 29, 2022
    Inventors: PAN DU, LINLIN ZHOU
  • Publication number: 20220213527
    Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.
    Type: Application
    Filed: October 8, 2021
    Publication date: July 7, 2022
    Inventors: Xiaohong WANG, Pan Du, Shidong Jia
  • Patent number: 11174503
    Abstract: Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: November 16, 2021
    Assignee: Predicine, Inc.
    Inventors: Xiaohong Wang, Pan Du, Shidong Jia
  • Publication number: 20210102256
    Abstract: Disclosed are systems and methods for diagnosing a disease status or progression of a disease comprising detection and correlation of methylation and expression level changes of cancer markers including PD-L1 in a biofluid sample from the patient. The systems and methods are similarly applicable to the detection and correlation of methylation and expression level changes in solid tissues. The present method utilized a barcoding method for analysis. The systems and methods can be used for predicting immunotherapy resistant cancer and monitoring therapy response.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 8, 2021
    Inventors: Shidong JIA, Pan DU, Zhixin ZHAO
  • Patent number: D991350
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: July 4, 2023
    Inventor: Pan Du