Patents by Inventor Panagiotis Benos

Panagiotis Benos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PARP genomic variants conferring resistance and sensitization to chemotherapy under inhibition
    Patent number: 10260108
    Abstract: A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of a PARP1 gene, wherein the presence of a mutation in the PARP1 gene indicates that the cancer can be treated with the PARP1 inhibitor, optionally in conjunction with the chemotherapeutic agent. In a specific, non-limiting example, the PARP1 inhibitor is verliparib (ABT-888).
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: April 16, 2019
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Hussein A. Tawbi, Petr Pancoska, Panagiotis Benos, Marjorie Romkes, Andrew J. Sedgewick, Irina Abecassis
  • PARP GENOMIC VARIANTS CONFERRING RESISTANCE AND SENSITIZATION TO CHEMOTHERAPY UNDER INHIBITION
    Publication number: 20170342498
    Abstract: A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of a PARP1 gene, wherein the presence of a mutation in the PARP1 gene indicates that the cancer can be treated with the PARP1 inhibitor, optionally in conjunction with the chemotherapeutic agent. In a specific, non-limiting example, the PARP1 inhibitor is verliparib (ABT-888).
    Type: Application
    Filed: October 30, 2015
    Publication date: November 30, 2017
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Hussein A. Tawbi, Petr Pancoska, Panagiotis Benos, Marjorie Romkes, Andrew J. Sedgewick, Irina Abecassis
  • MicroRNAs In Idiopathic Pulmonary Fibrosis
    Publication number: 20120045395
    Abstract: The present invention relates to the discovery that certain microRNAs are differentially expressed in Idiopathic Pulmonary Fibrosis. The present invention provides for diagnostic methods, therapeutic methods, and kits related to these differentially expressed microRNAs.
    Type: Application
    Filed: March 21, 2011
    Publication date: February 23, 2012
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Naftali Kaminski, Panagiotis Benos, David Corcoran, Kusum V. Pandit, Jadranka Milosevic, Hanadie Yousef