Patents by Inventor Panagiotis J. Vlachostergios

Panagiotis J. Vlachostergios has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKERS FOR SACITUZUMAB GOVITECAN THERAPY
    Publication number: 20210316003
    Abstract: The present invention relates to biomarkers of use for treating Trop-2 expressing cancer with an anti-Trop-2 ADC comprising an anti-Trop-2 antibody conjugated to an inhibitor of topoisomerase I, preferably SN-38 or DxD. The anti-Trop-2 ADC may be administered as a monotherapy or as a combination therapy with one or more anti-cancer agents, such as DDR inhibitors. Therapy with the ADC alone or in combination with other anti-cancer agents can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies. Preferably, the combination therapy has an additive effect on inhibiting tumor growth. Most preferably, the combination therapy has a synergistic effect on inhibiting tumor growth.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 14, 2021
    Applicant: Immunomedics, Inc.
    Inventors: Thomas M. Cardillo, Olivier Elemento, Bishoy M. Faltas, Trishna Goswami, Thorsten Rj Sperber, Scott T. Tagawa, Panagiotis J. Vlachostergios