Patents by Inventor Panayiotis P. Constantinides

Panayiotis P. Constantinides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME
    Publication number: 20230165878
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Application
    Filed: November 22, 2022
    Publication date: June 1, 2023
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • ORAL TESTOSTERONE ESTER FORMULATIONS AND METHODS OF TREATING TESTOSTERONE DEFICIENCY COMPRISING SAME
    Publication number: 20230105163
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Application
    Filed: July 22, 2022
    Publication date: April 6, 2023
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES
  • Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
    Patent number: 11426416
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: August 30, 2022
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
    Patent number: 11331325
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: May 17, 2022
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
    Patent number: 11179403
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: November 23, 2021
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
    Patent number: 11179402
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: November 23, 2021
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • METHODS OF TREATING TESTOSTERONE DEFICIENCY
    Publication number: 20210220374
    Abstract: Methods of treating a testosterone deficiency or its symptoms with a pharmaceutical formulation of testosterone esters are provided. The methods are designed to provide optimum serum testosterone levels over an extended period.
    Type: Application
    Filed: August 24, 2020
    Publication date: July 22, 2021
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES, James A. LONGSTRETH
  • PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF
    Publication number: 20200297756
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Inventors: Christopher KEVIL, Anthony GIORDANO, Douglas R. FLANAGAN, Panayiotis P. CONSTANTINIDES
  • Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
    Patent number: 10617696
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: April 14, 2020
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • ORAL TESTOSTERONE ESTER FORMULATIONS AND METHODS OF TREATING TESTOSTERONE DEFICIENCY COMPRISING SAME
    Publication number: 20200093836
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Application
    Filed: October 17, 2019
    Publication date: March 26, 2020
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES
  • PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF
    Publication number: 20200085861
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
    Type: Application
    Filed: October 11, 2019
    Publication date: March 19, 2020
    Inventors: Christopher KEVIL, Anthony GIORDANO, Douglas R. FLANAGAN, Panayiotis P. CONSTANTINIDES
  • METHODS OF TREATING TESTOSTERONE DEFICIENCY
    Publication number: 20200054648
    Abstract: Methods of treating a testosterone deficiency or its symptoms with a pharmaceutical formulation of testosterone esters are provided. The methods are designed to provide optimum serum testosterone levels over an extended period.
    Type: Application
    Filed: March 21, 2019
    Publication date: February 20, 2020
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES, James A. LONGSTRETH
  • ORAL TESTOSTERONE ESTER FORMULATIONS AND METHODS OF TREATING TESTOSTERONE DEFICIENCY COMPRISING SAME
    Publication number: 20200046732
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 13, 2020
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES
  • PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME
    Publication number: 20200046733
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 13, 2020
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES
  • Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
    Patent number: 10543219
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: January 28, 2020
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • Pharmaceutical formulations of nitrite and uses thereof
    Patent number: 10463689
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 5, 2019
    Assignee: Board of Supervisors of Louisiana State University
    Inventors: Christopher Kevil, Anthony Giordano, Douglas R. Flanagan, Panayiotis P. Constantinides
  • Pharmaceutical formulations of nitrite and uses thereof
    Patent number: 10307441
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: June 4, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher Kevil, Anthony Giordano, Douglas R Flanagan, Panayiotis P Constantinides
  • PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME
    Publication number: 20190070196
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Application
    Filed: November 7, 2018
    Publication date: March 7, 2019
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES
  • ORAL TESTOSTERONE ESTER FORMULATIONS AND METHODS OF TREATING TESTOSTERONE DEFICIENCY COMPRISING SAME
    Publication number: 20180110786
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Application
    Filed: October 3, 2017
    Publication date: April 26, 2018
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES
  • PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME
    Publication number: 20180078566
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Application
    Filed: October 3, 2017
    Publication date: March 22, 2018
    Inventors: Robert E. DUDLEY, Panayiotis P. CONSTANTINIDES