Patents by Inventor Pandu R. R. Gangula

Pandu R. R. Gangula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of esophageal motility disorder using sepiapterin, tetrahydrobiopterin and derivatives thereof
    Patent number: 9486456
    Abstract: The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: November 8, 2016
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Pankaj J. Pasricha, Pandu R. R. Gangula
  • TREATMENT FOR GASTROPARESIS USING SEPIAPTERIN
    Publication number: 20140249152
    Abstract: The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 4, 2014
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Pankaj J. Pasricha, Pandu R.R. Gangula
  • Treatment for gastroparesis using sepiapterin
    Patent number: 8669258
    Abstract: Embodiments of the invention are directed to the treatment of gastroparesis by administering sepiapterin.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: March 11, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Pankaj J. Pasricha, Pandu R. R. Gangula
  • Uses of tetrahydrobiopterin, sepiapterin and derivatives thereof
    Publication number: 20110098306
    Abstract: The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 28, 2011
    Inventors: Pankaj J. Pasricha, Pandu R.R. Gangula
  • Uses of tetrahydrobiopterin and derivatives thereof
    Patent number: 7863275
    Abstract: The present invention discloses methods of treating diabetic gastroparesis by administering tetrahydrobiopterin or a derivative thereof.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: January 4, 2011
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Pankaj J. Pasricha, Pandu R. R. Gangula
  • Uses of tetrahydrobiopterin and derivatives thereof
    Publication number: 20080207579
    Abstract: The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.
    Type: Application
    Filed: October 29, 2007
    Publication date: August 28, 2008
    Inventors: Pankaj J. Pasricha, Pandu R.R. Gangula