Abstract: A motor driving circuit and a method for detecting output phase loss are disclosed, which detect and integrate a three-phase direct current to generate a current integration, and to determine whether a motor configured in the motor driving circuit operates in a phase loss condition according to the current value of the current integration. When the current value of the current integration is a constant value, the motor driving circuit determines that the motor operates in a normal condition, and drives the motor continuously. When the current value of the current integration is a low current value (e.g., 0 A), the motor driving circuit determines that the motor operates in a phase loss condition, and stops driving the motor. Therefore, when the motor driving circuit and the method generate the higher current because of operating in the phase loss condition, it can avoid burning out the motor driving circuit.