Patents by Inventor Pankaj Devdatta REGE

Pankaj Devdatta REGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asymmetric synthesis of a substituted pyrrolidine-2-carboxamide
    Patent number: 9828340
    Abstract: The invention relates to a process for the preparation of 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid of the formula (I) as well as intermediates thereof and pharmaceutical preparations thereof, comprising the step of reacting a compound of the formula (IV) with a compound of the formula (V), as defined in the specification, in the presence of a chiral silver- or copper catalyst.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: November 28, 2017
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Daniel Fishlock, Chen Gu, Lianhe Shu, Pankaj Devdatta Rege, Keshab Sarma
  • ASYMMETRIC SYNTHESIS OF A SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDE
    Publication number: 20160002158
    Abstract: The present invention provides an improved method for the large scale production of the compound 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid.
    Type: Application
    Filed: February 18, 2014
    Publication date: January 7, 2016
    Applicant: Hoffmann-La Roche AG
    Inventors: Daniel FISHLOCK, Chen GU, Lianhe SHU, Pankaj Devdatta REGE, Keshab SARMA