Abstract: Provided herein are methods and compositions relating to variant nucleic acid libraries encoding for antibodies including single domain antibodies. Libraries generated using methods described herein have improved characteristics including improved binding affinity. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A system for establishing network reliability for a computer network includes a plurality of initiating nodes to transmit a plurality of packets across the network and a plurality of receiving nodes to receive the plurality of packets via the network. A portion of the plurality of packets transmitted from the initiating nodes are appended with identifiers that correspond to characteristics of entities using the network. The plurality of receiving nodes transmit acknowledgement receipts associated with packets appended with the identifiers to a network monitoring system that monitors quality of service associated with the characteristics.

Abstract: A device and method for providing end-to-end application onboarding. An application bundle is uploaded to a pre-production system and pre-production testing of the application bundle is requested. In response to the application bundle passing the pre-production testing, approval of the application bundle is received. In response to receiving the approval of the application bundle, quality assurance testing of the application bundle is performed in at least one pre-production test environment isolated from the production environment. In response to the application bundle passing the quality assurance testing in the at least one pre-production test environment isolated from the production environment, the application bundle is promoted to the production environment.

Abstract: Provided herein are methods and compositions relating to variant nucleic acid libraries encoding for antibodies including single domain antibodies. Libraries generated using methods described herein have improved characteristics including improved binding affinity. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A method of and system for enhanced local-device content discovery is disclosed. A method includes providing a local collection of content items and associated metacontent on a device. The metacontent describes the informational content of the corresponding content items. A remote catalog of metacontent items and information describing relationships between the metacontent items is provided. Input is received from the user for finding at least one desired content item and a search query is formed including at least one metacontent item of the remote catalog based on matching the input from the user with metacontent items of the catalog and further based on the information describing relationships between the metacontent items. A subset of content items of the local collection associated with metacontent that at least partially matches the search query is selected and presented on a display device based on at least one ranking criterion.

Abstract: The present disclosure provides user-interface methods and systems for submitting search requests to search engines and presenting search results therefrom customized using content preferences learned about a user, comprising sending query information to at least two search engines, including a query identifying desired content, and user information, including context information describing the environment in which the query information is being sent, and a user signature representing content preferences learned about the user; receiving at least one set of a search result and auxiliary information from the at least one search engine in response to sending the query information, including information describing attributes of the search result that led to the search result being chosen by the at least one search engine; ordering the at least one search result based at least in part on the auxiliary information; and presenting the ordered search results to the user.

Abstract: Provided herein are methods and compositions relating to prostaglandin D2 receptor 2 (DP2 or CRTH2R) libraries having nucleic acids encoding for a scaffold comprising a CRTH2R binding domain. CRTH2R libraries described herein encode for immunoglobulins including antibodies and single domain antibodies. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A system generates a probe packet including a probe flag and transmits the probe packet through a network tunnel to a destination computing system. The system receives from the destination computing system through the network tunnel an acknowledgment packet indicating receipt of the probe packet with the probe flag by the destination computing system. The system determines whether the transmitted probe packet and the received acknowledgment packet satisfy a packet loss condition. The system indicates packet loss based on the transmitted probe packet and the received acknowledgment packet satisfying the packet loss condition.

Abstract: In accordance with one or more embodiments of the invention, a method and system are provided of processing a search query entered by a user of a device having a text input interface with overloaded keys. The search query is directed at identifying an item from a set of items. Each of the items has one or more associated descriptors. The system receives from the user an ambiguous search query directed at identifying a desired item. The search query is a prefix substring of each of at least two words relating to the desired item. The system dynamically identifies a group of one or more items from the set of items having one or more descriptors matching the search query as the user enters each character of the search query. The system outputs identification of the one or more items of the identified group to be displayed on the device operated by the user.

Abstract: Management of end-to-end onboarding of application bundles is described. A dashboard user interface is presented for displaying information associated with at least one application bundle component and presenting a dashboard menu on the dashboard user interface for selecting the at least one application bundle component to create. A selection of the at least one application bundle component to create is received via the dashboard menu. Based on the selection, a creation user interface including a selectable control component to initiate creation of the at least one application bundle component is displayed. In response to receiving selection of the selectable control component, the at least one application bundle component is created.

Abstract: The present disclosure provides user-interface methods and systems for submitting search requests to search engines and presenting search results therefrom customized using content preferences learned about a user, comprising sending query information to at least two search engines, including a query identifying desired content, and user information, including context information describing the environment in which the query information is being sent, and a user signature representing content preferences learned about the user; receiving at least one set of a search result and auxiliary information from the at least one search engine in response to sending the query information, including information describing attributes of the search result that led to the search result being chosen by the at least one search engine; ordering the at least one search result based at least in part on the auxiliary information; and presenting the ordered search results to the user.

Abstract: The present invention relates to a polydixylitol polymer nucleic acid transporter (X-NC) prepared in a nanochain form, a method for preparing the same, and a technology for treating brain tumors by using the same, a nucleic acid transporter complex in which a therapeutic nucleic acid is linked to the nucleic acid transporter, and a pharmaceutical composition for gene therapy, comprising the complex as an active ingredient.

Abstract: In accordance with one or more embodiments of the invention, a method and system are provided of processing a search query entered by a user of a device having a text input interface with overloaded keys. The search query is directed at identifying an item from a set of items. Each of the items has one or more associated descriptors. The system receives from the user an ambiguous search query directed at identifying a desired item. The search query is a prefix substring of each of at least two words relating to the desired item. The system dynamically identifies a group of one or more items from the set of items having one or more descriptors matching the search query as the user enters each character of the search query. The system outputs identification of the one or more items of the identified group to be displayed on the device operated by the user.

Abstract: A computer system is used to initiate a process to configure an external accessory for use with at least a first device management application. The computer system displays a prompt that includes an option to initiate a process to configure the external accessory for use with at least a first device management application. While displaying the prompt, the computer system optionally receives a selection and/or an input corresponding to a selection of an option to initiate a process to configure the external accessory for use with at least a first device management application.

Abstract: Methods of and systems for dynamically rearranging search results into hierarchically organized concept clusters are provided. A method of searching for and presenting content items as an arrangement of conceptual clusters to facilitate further search and navigation on a display-constrained device includes providing a set of content items and receiving incremental input to incrementally identify search terms for content items. Content items are selected and grouped into sets based on how the incremental input matches various metadata associated with the content items. The selected content items are grouped into explicit conceptual clusters and user-implied conceptual clusters based on metadata in common to the selected content items. The clustered content items are presented according to the conceptual clusters into which they are grouped.

Abstract: Provided herein are methods and compositions relating to glucagon-like peptide-1 receptor (GLP1R) libraries having nucleic acids encoding for a scaffold comprising a GLP1R binding domain. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: Provided is a polydixylitol polymer gene transporter (VBXYP-P) containing vitamin B6 and a cancer stem cell-targeting peptide (TR-7) and a method for preparing the same. In addition, provided is a nucleic acid delivery complex in which a therapeutic nucleic acid is conjugated to the gene transporter, and a pharmaceutical composition for gene therapy containing the complex as an active ingredient. In addition, provided is the gene transporter, a gene delivery complex, and gene therapy using the same. It was observed that VBXYP-P of the present disclosure had a remarkably higher nucleic acid delivery rate to cancer stem cells than the pre-existing nucleic acid transporter, and when VBXYP-P was conjugated with DNA, the complex was almost free of cytotoxicity and permeated a blood brain barrier to exhibit remarkably high transformation efficiency for cancer stem cells inside a brain tumor.

Abstract: Methods of and systems for dynamically rearranging search results into hierarchically organized concept clusters are provided. A method of searching for and presenting content items as an arrangement of conceptual clusters to facilitate further search and navigation on a display-constrained device includes providing a set of content items and receiving incremental input to incrementally identify search terms for content items. Content items are selected and grouped into sets based on how the incremental input matches various metadata associated with the content items. The selected content items are grouped into explicit conceptual clusters and user-implied conceptual clusters based on metadata in common to the selected content items. The clustered content items are presented according to the conceptual clusters into which they are grouped.

Abstract: Provided herein are methods and compositions relating to glucagon-like peptide-1 receptor (GLP1R) libraries having nucleic acids encoding for a scaffold comprising a GLP1R binding domain. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A method of and system for enhanced local-device content discovery is disclosed. A method includes providing a local collection of content items and associated metacontent on a device. The metacontent describes the informational content of the corresponding content items. A remote catalog of metacontent items and information describing relationships between the metacontent items is provided. Input is received from the user for finding at least one desired content item and a search query is formed including at least one metacontent item of the remote catalog based on matching the input from the user with metacontent items of the catalog and further based on the information describing relationships between the metacontent items. A subset of content items of the local collection associated with metacontent that at least partially matches the search query is selected and presented on a display device based on at least one ranking criterion.