Abstract: An example method of encoding a video includes selecting blocks of pixels in a frame of the video, the blocks having luminance (Y) blocks, red color difference (Cr) blocks, and blue color difference (Cb) blocks; performing intra-estimation based on reconstructed pixels of at the blocks of pixels to generate predicted blocks and then subtracting the predicted blocks from the blocks of pixels to generate residual data, the residual data comprising respective residual data for the Y-blocks interleaved with respective residual data for the Cr-blocks and the Cb-blocks; and generating new reconstructed pixels using a pipeline of a video encoder by processing the residual data for the blocks.