Abstract: Disclosed herein is a fluid dispenser comprising a barrel defining a longitudinal axis terminating at a first fluid delivery end region; a body movable along the barrel relative to the first fluid delivery end region, the body including a needle carrier, a plunger and a capsule carrier therebetween, a latch interface between the body and the barrel and responsive to a release force therebetween caused by compressive engagement of the barrel at a fluid delivery site on a patient, to enable travel of the plunger and capsule carrier toward the needle carrier, to a dispensing configuration in which an upstream end of the needle pierces the capsule and projects form the first fluid delivery end region to deliver a fluid to the fluid delivery site.

Abstract: A film-based dosage form is provided. The dosage form includes a film base comprising a film-forming agent, a plasticizer and a solvent; and a matrix incorporated within the film base which comprises a target molecule that exhibits low aqueous solubility which is encapsulated and solubilized in a micellar formulation comprising a detergent in an aqueous solvent. The dosage form is particularly useful for administration of cannabinoids.

Abstract: An orally administrable micellar composition is provided. The composition comprises: i) at least one physiologically acceptable film forming agent in an amount ranging from about 30 to 80% by wt in a pharmaceutically acceptable aqueous solvent combined with ii) a micellar composition comprising a drug encapsulated in micelles of 50-1000 nm in size formed by micelle-forming compounds, in a pharmaceutically acceptable aqueous solvent.

Abstract: A formulation for solubilizing a water insoluble pharmaceutical agent is provided. The formulation comprises: a water-insoluble pharmaceutical agent, a detergent, an enzyme that breaks down lipids, proteins, and/or starches, a plasticizing agent, an emulsifying agent and an aqueous solvent. A method of making the formulation is also provided.

Abstract: An orally administrable micellar composition is provided. The composition comprises: i) at least one physiologically acceptable film forming agent in an amount ranging from about 30 to 80% by wt in a pharmaceutically acceptable aqueous solvent combined with ii) a micellar composition comprising a drug encapsulated in micelles of 50-1000 nm in size formed by micelle-forming compounds, in a pharmaceutically acceptable aqueous solvent.

Abstract: A method for non-surgically reducing localized adipose tissue in a patient is provided. The method comprises topically administering to a site at or proximate adipose tissue, with massage at the site of administration, a composition comprising: at least one biologically compatible pharmacologically active detergent selected from the group consisting of a lipophilic detergent, a hydrophilic detergent, an ionic detergent, a non-ionic detergent, a zwitterionic detergent, a glyceride and a bile acid or salt thereof in a concentration ranging from about 0.5% to about 30% by wt of the composition and at least one phospholipid. In one embodiment, a novel composition comprising deoxycholic acid or a salt thereof at a concentration ranging from about 0.5% to about 30% by wt, and phosphatidylcholine at a concentration ranging from about 0.1% to about 2% by wt, in a cream base is also provided.

Abstract: A film-based dosage form is provided. The dosage form includes a film base comprising a film-forming agent, a plasticizer and a solvent; and a matrix incorporated within the film base which comprises a target molecule that exhibits low aqueous solubility which is encapsulated and solubilized in a micellar formulation comprising a detergent in an aqueous solvent. The dosage form is particularly useful for administration of cannabinoids.

Abstract: Disclosed herein is a fluid dispenser comprising a barrel defining a longitudinal axis terminating at a first fluid delivery end region; a body movable along the barrel relative to the first fluid delivery end region, the body including a needle carrier, a plunger and a capsule carrier therebetween, a latch interface between the body and the barrel and responsive to a release force therebetween caused by compressive engagement of the barrel at a fluid delivery site on a patient, to enable travel of the plunger and capsule carrier toward the needle carrier, to a dispensing configuration in which an upstream end of the needle pierces the capsule and projects form the first fluid delivery end region to deliver a fluid to the fluid delivery site.

Abstract: An orally administrable micellar composition is provided. The composition comprises a pharmaceutical agent encapsulated in micelles formed by at least one micelle-forming compound in a pharmaceutically acceptable aqueous solvent comprising an alkali metal salicylate and a pharmaceutically acceptable edetate combined with at least one physiologically acceptable film forming agent.

Abstract: A formulation for solubilizing a water insoluble pharmaceutical agent is provided. The formulation comprises: a water-insoluble pharmaceutical agent, a detergent, an enzyme that breaks down lipids, proteins, and/or starches, a plasticizing agent, an emulsifying agent and an aqueous solvent. A method of making the formulation is also provided.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: Disclosed herein is a fluid dispenser comprising a barrel defining a longitudinal axis terminating at a first fluid delivery end region; a body movable along the barrel relative to the first fluid delivery end region, the body including a needle carrier, a plunger and a capsule carrier therebetween, a latch interface between the body and the barrel and responsive to a release force therebetween caused by compressive engagement of the barrel at a fluid delivery site on a patient, to enable travel of the plunger and capsule carrier toward the needle carrier, to a dispensing configuration in which an upstream end of the needle pierces the capsule and projects form the first fluid delivery end region to deliver a fluid to the fluid delivery site.

Abstract: The invention relates to a novel stabilized and solubilized topical formulation for cosmetic improvements and methods of making the same comprising multiplexed molecular penetration enhancers and essential and semi-essential amino acid protein binders for the topical application and transdermal delivery of one or more active ingredients and/or pharmaceutical agents. The invention further relates to the use of the topical formulation in connection with the providing of cosmetic improvements in individuals.

Abstract: A composition comprising a tetrahydrocannabinoid compound, a second cannabinoid and a corticosteroid is provided. The composition is useful to treat psoriasis and related conditions in a mammal.

Abstract: An orally administrable micellar composition is provided. The composition comprises a pharmaceutical agent encapsulated in micelles formed by at least one micelle-forming compound in a pharmaceutically acceptable aqueous solvent comprising an alkali metal salicylate and a pharmaceutically acceptable edetate combined with at least one physiologically acceptable film forming agent.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: A composition comprising a tetrahydrocannabinoid compound, a second cannabinoid and a corticosteroid is provided. The composition is useful to treat psoriasis and related conditions in a mammal.

Abstract: Lipid and/or detergent containing compositions, optionally formulated for enhanced penetration in a carrier, for non-invasive therapy of aggregated deposits of adipose tissue and other conditions.

Abstract: The invention relates to a novel solubilized small molecule topical formulation for the transdermal delivery of small molecule agents comprising: a small molecule agent, one or more micelle forming compounds, one or more skin penetration enhancers, a surfactant, and one or more solvents, wherein the small molecule agent is solubilized in the solvent. The invention further relates to the use of the topical formulation as well as the process for making the topical formulation.

Abstract: The invention relates to a novel solubilized benzoyl peroxide topical formulation for the treatment of acne comprising: benzoyl peroxide, one or more micelle forming compounds, one or more skin penetration enhancers, a surfactant, and one or more solvents, wherein the benzoyl peroxide is solubilized in the solvent. The invention further relates to the use of the topical formulation as well as the process for making the topical formulation.