Abstract: A cardiac pacing device to be disposed in a heart between an atrium and an atrial appendage protruding from the atrium includes a blocker and a regulator attached to the blocker. The blocker is configured to occlude the atrial appendage. The regulator is configured to contact the heart when the blocker is positioned between the atrium and the atrial appendage to occlude the atrial appendage in order to regulate a cardiac rhythm of the heart accordingly.

Abstract: A method for determining a human subject's risk of developing acute kidney injury (AKI) from acute myocardial infarction (AMI) includes: obtaining a blood sample; determining at least two miRNA expression levels therein, which are selected from miR-23a-3p, miR-24-3p, and miR-145-5p expression levels; calculating probability of developing AKI from AMI based on the at least two miRNA expression levels and a logistic regression model; comparing the probability with a predetermined standard; and determining that the human subject is at the risk of developing AKI when the probability is higher than the predetermined standard. A composition may be administered to the human subject for inhibiting development of AKI, if any.

Abstract: Provided herein are synthetic peptides and methods for treating cardiorespiratory diseases, particularly cardiopulmonary disorder (CPD) by use of the synthetic peptides. The present synthetic peptide has the amino acid sequence of X1EX2LRVANEVTLN (SEQ ID NO: 1), in which X1 is tyrosine (Y) or phenylalanine (F), and X2 is alanine (A) or cysteine (C). In preferred embodiments, an effective amount of the present synthetic peptide is administered to a subject suffering from CPD to ameliorate or alleviate symptoms associated therewith.

Abstract: The present invention provides a catheter device. This novel catheter device comprises: a catheter, a catheter sheath, a guide wire, a tapered head, a helical structure, and a rotary member. When the catheter is inserted through a blood vessel and stopped by a plaque, it is able to operate the rotary member to rotate the catheter, such that a blockage region of the plaque for the catheter is formed with a through hole therein. Therefore, the guide wire can pass through the through hole of the blockage region, and then the front-end of the catheter can subsequently pass through the blockage region with the forward movement of the guide wire. Consequently, a balloon angioplasty or a stent implantation can easily be conducted in the blockage region of the artery.

Abstract: A cardiac pacing device to be disposed in a heart between an atrium and an atrial appendage protruding from the atrium includes a blocker and a regulator attached to the blocker. The blocker is configured to occlude the atrial appendage. The regulator is configured to contact the heart when the blocker is positioned between the atrium and the atrial appendage to occlude the atrial appendage in order to regulate a cardiac rhythm of the heart accordingly.

Abstract: A method for determining a human subject's risk of developing acute kidney injury (AKI) from acute myocardial infarction (AMI) includes: obtaining a blood sample; determining at least two miRNA expression levels therein, which are selected from miR-23a-3p, miR-24-3p, and miR-145-5p expression levels; calculating probability of developing AKI from AMI based on the at least two miRNA expression levels and a logistic regression model; comparing the probability with a predetermined standard; and determining that the human subject is at the risk of developing AKI when the probability is higher than the predetermined standard. A composition may be administered to the human subject for inhibiting development of AKI, if any.

Abstract: A method for integrating diagnostic data, includes steps of: reading a plurality of medical records each including an identity information and a medical history that corresponds to the identify information from a first database and a second database; determining whether any one of the medical records satisfies a user defined condition; and, when affirmative, generating an integrated medical information indicating each of the medical records that satisfies the user defined condition.

Abstract: A method for treating or preventing infarction of a patient comprising administering a hepsin antagonist with a dosage effective to suppress or inactivate hepsin's expression over a sustained period.

Abstract: A method for treating macular degeneration and/or treating optic nerve degeneration of a patient comprises administering topiramate with a dosage pharmaceutically effective to suppress degeneration or induce growth of new optic nerve fibers over a sustained period.