Abstract: A method of manufacturing a multicolor-foamed shoe body by supercritical foaming includes step S1 to step S3: step S1: provide a plurality of cold shot model molds and inject a plurality of foaming materials in different colors into a cavity of each of the cold shot model molds to form a plurality of cold shot models in different colors that is unfoamed; step S2: place the cold shot models in a hot-pressing mold for hot pressing to make a contacting surface of any two of the cold shot models that are adjacent engage with each other due to heating to foam a semi-finished product; and step S3: place the semi-finished product in a supercritical foaming autoclave for foam molding to obtain the multicolor-foamed shoe body. Additionally, the multicolor-foamed shoe body manufactured by the method is also disclosed in the present invention.