Patents by Inventor Paola Civaroli

Paola Civaroli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline CDC7 inhibitor salts
    Patent number: 8658662
    Abstract: The present invention relates to novel crystalline salts of a CDC7 or CDC7/CDKs inhibitor, to a novel crystal form of the corresponding free base, to a process for their preparation, to hydrates, solvates and polymorphs of such new salt forms, to their use in therapy and to pharmaceutical compositions containing them. Such crystal salts are selected from L-asparate, hemifumarate, hydrochloride, maleate, mesylate, sulfate, L-tartrate or phosphate salts of 5-(2-amino-pyrimidin-4-yl)-2-(2,4-dichloro-phenyl)-1H-pyrrole-3-carboxylic acid amide.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: February 25, 2014
    Assignee: Nerviano Medical Sciences S.r.l.
    Inventors: Massimo Zampieri, Ermes Vanotti, Paola Civaroli, Maria Gioia Fornaretto
  • CRYSTALLINE CDC7 INHIBITOR SALTS
    Publication number: 20120245189
    Abstract: The present invention relates to novel crystalline salts of a CDC7 or CDC7/CDKs inhibitor, to a novel crystal form of the corresponding free base, to a process for their preparation, to hydrates, solvates and polymorphs of such new salt forms, to their use in therapy and to pharmaceutical compositions containing them. Such crystal salts are selected from L-asparate, hemifumarate, hydrochloride, maleate, mesylate, sulfate, L-tartrate or phosphate salts of 5-(2-amino-pyrimidin-4-yl)-2-(2,4-dichloro-phenyl)-1H-pyrrole-3-carboxylic acid amide.
    Type: Application
    Filed: November 5, 2010
    Publication date: September 27, 2012
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Massimo Zampieri, Ermes Vanotti, Paola Civaroli, Maria Gioia Fornaretto
  • Oral formulations for anti-tumor compounds
    Patent number: 7201913
    Abstract: The present invention relates to a semi-solid filling medium which comprises a camptothecin derivative; a pharmaceutically acceptable carrier matrix which is a polyglycolized glyceride; and an effective thickening-reducing and stabilizing-promoting amount of one or more pharmaceutically acceptable excipients.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: April 10, 2007
    Assignee: Pfizer Inc.
    Inventors: Lorena Muggetti, Alessandro Martini, Paola Civaroli, Christopher James
  • Pharmaceutical formulations in hydroxypropylmethylcellulose capsules
    Patent number: 6569452
    Abstract: An oral pharmaceutical formulation, which comprises, in a hydroxypropylmethylcellulose capsule, a camptothecin analogue dispersed or solubilized in a semi-solid matrix of a polyethyleneglycol with a molecular weight ranging from 400 to 20000.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: May 27, 2003
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Paola Civaroli, Lorena Muggetti, Alessandro Martini