Patents by Inventor Paola Cosmina

Paola Cosmina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asporogenous strain of bacillus subtilis and its use as a host for the preparation of heterologous products
    Patent number: 6284490
    Abstract: The invention relates to a new asporogenous strain of Bacillus subtilis which has been deposited at the Centraalbureau Voor Schimmelcultures under the number CBS 432.90. This strain, which shows a frequency of reversion to the formation of spores of less than about 10−8 and good plasmid stability, is suitable as a host in a host-vector system for the preparation of heterologous products of interest.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: September 4, 2001
    Assignee: Eniricerche S.p.A.
    Inventors: Gianni Frascotti, Paola Cosmina, Guido Grandi
  • Method for genetically manipulating peptide synthetases
    Patent number: 5652116
    Abstract: Disclosed is a novel method for the in vivo and in vitro synthesis of modified peptides, using either engineered microorganisms capable of expressing peptide synthetases with modified substrate specificity, or peptide synthetases extracted from said microorganisms.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: July 29, 1997
    Assignee: Eniricerche S.p.A.
    Inventors: Guido Grandi, Francesca De Ferra, Giuliano Galli, Paola Cosmina
  • Plasmid vector for expression in bacillus and used for cloning the structural gene which codes for the human growth hormone and a method of producing the hormone
    Patent number: 5334531
    Abstract: The description relates to a plasmid vector expression in Bacillus and used for cloning the structural gene which codes for the human growth hormone, a recombinant DNA molecule comprising plasmid vector and the structural gene of the human growth hormone and a method of preparing the hormone comprising inserting the recombinant DNA molecule into strains of Bacillus and cultivating the resulting transformed strains in a suitable culture environment and recovering the thus-synthesized hormone from the cells.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: August 2, 1994
    Assignee: Eniricerche S.p.A
    Inventors: Marina Del Bue, Paola Cosmina, Elisabetta Franchi, Guido Grandi
  • Mutant of Bacillus subtilis
    Patent number: 5264363
    Abstract: The present invention relates to a stable mutant of Bacillus subtilis which can produce surfactin with high yields, a method of producing surfactin with the use of the strain and the use of the surfactin obtained for pharmaceutical, energy and environmental problems.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: November 23, 1993
    Assignee: Eniricerche S.p.A.
    Inventors: Paolo Carrera, Paola Cosmina, Guido Grandi
  • Method of producing surfactin with the use of mutant of Bacillus subtilis
    Patent number: 5227294
    Abstract: The present invention relates to a stable mutant of Bacillus subtilis which can produce surfactin with high yields, a method of producing surfactin with the use of the strain and the use of the surfactin obtained for pharmaceutical, energy and environmental problems.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: July 13, 1993
    Assignee: Eniricerche S.p.A.
    Inventors: Paolo Carrera, Paola Cosmina, Guido Grandi