Patents by Inventor Paola Fassi

Paola Fassi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of intermediates for the preparation of pramipexol
    Patent number: 7662610
    Abstract: A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof, wherein R1 is straight or branched C1-C6 alkyl, optionally substituted with phenyl; (the asterisk * and R defined above), with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: February 16, 2010
    Assignee: Dipharma Francis s.r.l.
    Inventors: Sergio Riva, Paola Fassi, Michele Scarpellini, Pietro Allegrini, Gabriele Razzetti
  • Process for the preparation of (?) modafinil
    Patent number: 7316918
    Abstract: An enzymatic process for the preparation of intermediates useful in the synthesis of (?) modafinil.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: January 8, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Sergio Riva, Paola Fassi, Pietro Allegrini, Gabriele Razzetti
  • SYNTHESIS OF INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOL
    Publication number: 20070166814
    Abstract: A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R, S) enantiomers, or a salt thereof, wherein R1 is straight or branched C1-C6 alkyl, optionally substituted with phenyl; the asterisk * and R defined above), with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.
    Type: Application
    Filed: January 11, 2007
    Publication date: July 19, 2007
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Sergio RIVA, Paola Fassi, Michele Scarpellini, Pietro Allegrini, Gabriele Razzetti
  • Process for the preparation of (-) modafinil
    Publication number: 20070087422
    Abstract: An enzymatic process for the preparation of intermediates useful in the synthesis of (?) modafinil.
    Type: Application
    Filed: October 17, 2006
    Publication date: April 19, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Sergio Riva, Paola Fassi, Pietro Allegrini, Gabriele Razzetti