Patents by Inventor Paola Ferrante

Paola Ferrante has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AZABICYCLIC SHP2 INHIBITORS
    Publication number: 20240109900
    Abstract: The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I).
    Type: Application
    Filed: February 8, 2022
    Publication date: April 4, 2024
    Inventors: Alina CIAMMAICHELLA, Romano DI FABIO, Federica FERRIGNO, Paola FEZZARDI, Christian MONTALBETTI, Alessia PETROCCHI, Nicola RELITTI, Ilaria ROSSETTI, Alessio SFERRAZZA, Esther TORRENTE, Luca FERRANTE, Alessandro GRILLO
  • Carotenoid dioxygenase and methods for the biotechnological production in microorganisms and plants of compounds derived from saffron
    Patent number: 9969989
    Abstract: The present invention relates to a new carotenoid dioxygenase and methods for the biological production in microorganisms and plants of compounds with high added value derived from saffron.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 15, 2018
    Assignee: AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENER- GIA E LO SVILUPPO ECONOMICO SOSTENIBILE (ENEA)
    Inventors: Giovanni Giuliano, Paola Ferrante, Sarah Frusciante, Gianfranco Diretto, Marco Pietrella, Salim Al-Babili
  • A CAROTENOID DIOXYGENASE AND METHODS FOR THE BIOTECHNOLOGICAL PRODUCTION IN MICROORGANISMS AND PLANTS OF COMPOUNDS DERIVED FROM SAFFRON
    Publication number: 20170175089
    Abstract: The present invention relates to a new carotenoid dioxygenase and methods for the biological production in microor-ganisms and plants of compounds with high added value derived from saffron.
    Type: Application
    Filed: July 23, 2015
    Publication date: June 22, 2017
    Inventors: Giovanni Giuliano, Paola Ferrante, Sarah Frusciante, Gianfranco Diretto, Marco Pietrella, Salim Ali-Babili
  • SYSTEM FOR INDUCIBLE GENE EXPRESSION IN CHLAMYDOMONAS
    Publication number: 20110033938
    Abstract: The unicellular green alga Chlamydomonas reinhardtii is currently used in many biotechnological applications for the production of biopharmaceuticals and of biohydrogen. These applications require the tightly controlled expression of genes. The present invention consists in the development and use of gene cassettes and culture growth media to obtain inducible, reversible expression of genes in Chlamydomonas. These cassettes contain the Chlamydomonas cytochrome c6 (Cyc6) promoter. It is already known that the Cyc6 promoter, joined to a DNA sequence, controls its transcription on the basis of the concentrations of copper (Cu2+) and nickel (Ni2+) ions in the growth medium (Quinn et al., 2003). In the present invention, the Cyc6 promoter activity was increased up to 20 times, as measured by the activity of an enzyme placed under its control, through the use of transcriptional enhancers, as for example the first intron of Rbcs2 gene and growth media with reduced amounts of transition metals and EDTA.
    Type: Application
    Filed: February 25, 2009
    Publication date: February 10, 2011
    Inventors: Giovanni Giuliano, Paola Ferrante