Patents by Inventor Paola Magnaghi

Paola Magnaghi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GEM-DISUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IDH INHIBITORS
    Publication number: 20230000871
    Abstract: The present invention relates to certain gem-disubstituted heterocyclic compounds, which modulate the activity of Isocitrate Dehydrogenase (IDH). The compounds of this invention are therefore useful in treating diseases caused by mutated IDH1 and/or mutated IDH2 enzyme and/or IDH1 wild type (wt) enzyme. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: October 29, 2020
    Publication date: January 5, 2023
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Francesco CASUSCELLI, Teresa DISINGRINI, Paola MAGNAGHI, Stefano NUVOLONI, Paolo ORSINI
  • HETEROCONDENSED PYRIDONES COMPOUNDS AND THEIR USE AS IDH INHIBITORS
    Publication number: 20210206759
    Abstract: The present invention relates to certain substituted heterocondensed pyridone analogues of formula (I) which modulate the activity of Isocitrate Dehydrogenase (IDH). The compounds of this invention are therefore useful in treating diseases caused by mutated IDH1 and/or mutated IDH2 enzyme and/or IDH1 wild type enzyme, in particular cancer, cell proliferative disorders and immune-related disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 8, 2021
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Elena CASALE, Francesco CASUSCELLI, Teresa DISINGRINI, Paola MAGNAGHI, Beatrice MALGESINI, Ilaria MOTTO, Stefano NUVOLONI
  • Human NIM1 kinase
    Publication number: 20030087317
    Abstract: The invention provides a human NIM1 kinase, an encoding nucleic acid molecule, and an antibody that specifically binds the protein. The invention also provides for the use of these compositions in the characterization, diagnosis, and treatment of disorders associated NIM1 kinase expression.
    Type: Application
    Filed: July 11, 2002
    Publication date: May 8, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Angela Molteni, Paola Magnaghi, Roberta Bosotti, Emanuela Scacheri, Antonella Isacchi, David M. Hodgson
  • Human NIM1 kinase
    Patent number: 6458561
    Abstract: The invention provides a nucleic acid molecule which encodes the human NIM1 kinase. It also provides for the use of the nucleic acid molecule, fragments, variants and complements thereof and of the protein, portions thereof and antibodies thereto for characterization, diagnosis, evaluation, treatment, or prevention of disorders associated with expression. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic organism or model system.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: October 1, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Angela Molteni, Paola Magnaghi, Roberta Bosotti, Emanuela Scacheri, Antonella Isacchi, David M. Hodgson