Patents by Inventor Paola Magotti

Paola Magotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • hAM15-52 ANALOGUES WITH IMPROVED AMYLIN RECEPTOR (hAMY3R) POTENCY
    Publication number: 20240101634
    Abstract: The present invention relates to hAM15-52 analogues with improved amylin receptor (hAMY3R) potency (hAMY3R-EC50?250 pM) and which are largely based on the sequence of the human adrenomedullin fragment hAM15-52. The invention further relates to hAM15-52 analogues that are selective amylin receptor (hAMY3R) agonists (hAMY3R-EC50?250 pM and an hAM1R-EC50?25 nM) and which are largely based on the sequence of the human adrenomedullin fragment hAM15-52. The hAM15-52 analogues according to the invention maintain the good physical stability of hAM15-52. The invention further relates to pharmaceutical compositions comprising such polypeptides and their use in the treatment of a medical condition such as obesity, NASH and/or diabetes.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 28, 2024
    Applicant: GUBRA A/S
    Inventors: Jens Christian Frøslev NIELSEN, Kristoffer Tobias, Gustav RIGBOLT, Esben Matzen BECH, Morten LUNDH, Paola MAGOTTI, Borja BALLARiN-GONZÁLEZ, Søren Ljungberg PEDERSEN, Nieis VRANG
  • Modified lipidated relaxin B chain peptides and their therapeutic use
    Patent number: 11725036
    Abstract: A biologically active single chain Relaxin peptide having the formula Nter-Ac-L-E-G-R-E-K-V-R-A-X19-I-X21-X22-E-G-X25-S-T-F-S-X30-R-A-X33-NH2-Cter, or a salt of solvate thereof, is described.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: August 15, 2023
    Assignee: Sanofi
    Inventors: Olivier Duclos, Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete
  • MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE
    Publication number: 20210292387
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO 105): Nter-AC-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S- X27-X28-X29-X30-X31-X32-X33-NH2-Cter or a salt or solvate thereof. It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.
    Type: Application
    Filed: October 30, 2020
    Publication date: September 23, 2021
    Inventors: Olivier DUCLOS, Stéphane ILLIANO, Sergio MALLART, Claire MINOLETTI-HOCHEPIED, Elisabetta BIANCHI, Raffaele INGENITO, Paola MAGOTTI, Alessia SANTOPRETE
  • Modified lipidated Relaxin B chain peptides and their therapeutic use
    Patent number: 10988523
    Abstract: Provided is a biologically active single chain Relaxin peptide having the following formula (I): Nter-Ac-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(K)d-(X35)e-(gE)f-X37-Cter; or a salt or solvate thereof. Also provided is a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 27, 2021
    Assignee: SANOFI
    Inventors: Denis Brasseur, Olivier Duclos, Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Frank Marguet, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete
  • Modified relaxin B chain peptides and their therapeutic use
    Patent number: 10988524
    Abstract: Provided is a biologically active single chain Relaxin peptide having the following formula (I): Nter-X-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(X34)d-NH2-Cter. Also provided is a pharmaceutical composition comprising at least one peptide of the invention, or a pharmaceutically acceptable salt or a solvate thereof. Further provided is the peptide, a pharmaceutically acceptable salt or solvate thereof, or the pharmaceutical composition for use as a medicament.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 27, 2021
    Assignee: SANOFI
    Inventors: Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Frank Marguet, Olivier Duclos, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete
  • Modified lipidated Relaxin B chain peptides and their therapeutic use
    Patent number: 10961295
    Abstract: Provided is a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO 105): Nter-Ac-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-X31-X32-X33-NH2-Cter or a salt or solvate thereof. Also provided is a pharmaceutical composition comprising at least one biologically active single chain Relaxin peptide. Uses of the peptide or the pharmaceutical composition as a medicament are also provided.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 30, 2021
    Assignee: SANOFI
    Inventors: Olivier Duclos, Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete
  • MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE
    Publication number: 20190233494
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO 105): Nter-Ac-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30—X31—X32—X33—NH2—Cter or a salt or solvate thereof. It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Olivier DUCLOS, Stéphane ILLIANO, Sergio MALLART, Claire MINOLETTI-HOCHEPIED, Elisabetta BIANCHI, Raffaele INGENITO, Paola MAGOTTI, Alessia SANTOPRETE
  • MODIFIED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE
    Publication number: 20190233495
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO:65): Nter-X-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(X34)d-NH2-Cter It also concerns a pharmaceutical composition comprising at least one peptide of the invention, or a pharmaceutically acceptable salt or a solvate thereof, and the peptide, a pharmaceutically acceptable salt or solvate thereof, or the pharmaceutical composition, for its use as a medicament.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Stéphane ILLIANO, Sergio MALLART, Claire MINOLETTI-HOCHEPIED, Frank MARGUET, Olivier DUCLOS, Elisabetta BIANCHI, Raffaele INGENITO, Paola MAGOTTI, Alessia SANTOPRETE
  • MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE
    Publication number: 20190233493
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I): Nter-Ac-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(K)d-(X35)e-(gE)f-X37-Cter; or a salt or solvate thereof. It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Denis Brasseur, Olivier Duclos, Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Frank Marguet, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete